Zaturinsky B, Naveh N, Saks D, Solomon A S
Maurice and Gabriela Goldschleger Eye Research Institute, Chaim Sheba Medical Center, Tel Aviv University, Sackler Faculty of Medicine, Tel Hashomer, Israel.
Ophthalmic Surg. 1990 Jun;21(6):431-4.
We tried applying a specially-designed cryoprobe to the posterior capsule as well as adding heparin, an anticoagulative, anti-inflammatory compound, to the anterior chamber irrigation solution in an attempt to inhibit secondary cataract formation following a planned extracapsular lens extraction in 36 rabbits. The first group received both cryo treatment and heparin; a second group received heparin without cryo treatment; a third group received neither heparin nor cryo treatment. Complete opacification of the lens developed 3 months after the operation in all the rabbits not treated with heparin, and in 50% of those that received heparin. The addition of cryo treatment to the heparin-treated rabbits further reduced opacification by 20%. We conclude that in rabbits, cryo treatment, combined with intracameral administration of heparin during surgery, has a significant inhibitory effect on secondary cataract formation.
我们尝试将一种特别设计的冷冻探头应用于后囊，并在36只兔子的前房冲洗液中添加肝素（一种抗凝、抗炎化合物），以抑制计划性囊外晶状体摘除术后继发性白内障的形成。第一组接受冷冻治疗和肝素；第二组接受肝素但未接受冷冻治疗；第三组既未接受肝素也未接受冷冻治疗。在未接受肝素治疗的所有兔子以及接受肝素治疗的50%兔子中，术后3个月晶状体完全混浊。对接受肝素治疗的兔子增加冷冻治疗可使混浊程度进一步降低20%。我们得出结论，在兔子中，冷冻治疗与术中前房内注射肝素相结合，对继发性白内障的形成具有显著的抑制作用。
