Shock J P, Zalta A H
Ophthalmic Surg. 1982 Feb;13(2):125-9.
In an attempt to inhibit secondary cataract formation by destroying the subcapsular lens epithelium, a defined amount of freeze was applied to the anterior capsule of one eye of 16 New Zealand white rabbits just prior to a planned extracapsular cataract extraction of both eyes using phacofragmentation. The rabbits were sacrificed eight weeks after surgery and the secondary cataracts were dissected from the eyes. The degree of secondary cataract formation was evaluated by two independent observers and grading systems. Overall, 14 of 16 rabbits, or 88%, had a significant (P less than .01) reduction of secondary cataract in the treated eye as compared to the control eye. This study demonstrates that freezing of the subcapsular lens epithelium prior to a planned extracapsular cataract extraction in rabbits can significantly diminish secondary cataract formation. However because of the present difficulty in controlling the extent of the freeze to the surrounding ocular tissues with current cryoprobes, this procedure is not yet applicable in humans.
为了通过破坏晶状体囊下上皮细胞来抑制后发性白内障的形成，在计划对16只新西兰白兔的双眼进行超声乳化白内障囊外摘除术前，对其中一只眼的前囊膜施加一定量的冷冻。术后八周处死兔子，并从眼中取出后发性白内障。由两名独立观察者使用分级系统评估后发性白内障的形成程度。总体而言，16只兔子中有14只（即88%），其治疗眼的后发性白内障与对照眼相比有显著（P小于0.01）减少。这项研究表明，在计划对兔子进行白内障囊外摘除术前冷冻晶状体囊下上皮细胞可显著减少后发性白内障的形成。然而，由于目前使用冷冻探头难以控制对周围眼组织的冷冻范围，该方法尚未应用于人类。
