Brown G C, Tasman W S, Naidoff M, Schaffer D B, Quinn G, Bhutani V K
Retina Service, Wills Eye Hospital, Philadelphia, PA.
Ophthalmology. 1990 Jul;97(7):855-8. doi: 10.1016/s0161-6420(90)32491-0.
Eighty infants with proliferative retinopathy of prematurity (ROP) were treated with peripheral retinal cryoablation. Among the serious systemic complications encountered were three instances of respiratory arrest and one of cardiorespiratory arrest. Recommendations that may help prevent these adverse systemic effects in premature infants include: (1) avoidance of excess subconjunctival anesthetic doses, (2) preoperative administration of systemic atropine to minimize the oculocardiac reflex, (3) consideration of an analgesic agent to decrease the pain and exhaustion, and (4) cardiorespiratory monitoring in a hospital setting, with an intravenous line in place, at the time of treatment.
80例早产儿增生性视网膜病变（ROP）接受了周边视网膜冷冻消融治疗。所遇到的严重全身并发症包括3例呼吸骤停和1例心肺骤停。有助于预防早产儿这些不良全身影响的建议包括：（1）避免结膜下麻醉剂剂量过大；（2）术前给予全身阿托品以尽量减少眼心反射；（3）考虑使用镇痛剂以减轻疼痛和疲劳；（4）在医院环境中进行治疗时，在建立静脉通路的情况下进行心肺监测。
