Keusch Stephan, Speich Rudolf, Treder Ulla, Ulrich Somaini Silvia
Clinic for Pulmonology, Heart-Vessel-Thorax Department, Zurich, Switzerland.
Respiration. 2013;86(5):402-6. doi: 10.1159/000350441. Epub 2013 Jun 27.
Intravenous prostanoid therapy is one cornerstone of therapy for patients with pre-capillary pulmonary hypertension (PH). Long-term central venous catheters expose patients to infectious complications.
We report the incidence of catheter-related infection (CRI) and the spectrum of bacteria for ambulatory PH patients treated with iloprost via non-tunnelled central venous catheters from our Swiss referral centre in Zurich.
Data from 15 PH patients treated with intravenous iloprost between May 2000 and June 2012 were reviewed.
We found 11 CRI in 4 cases by two different organisms. Pathogens found were Brevibacterium (55%), Micrococcus luteus (18%), coagulase-negative Staphylococcus (9%) and Staphylococcus aureus (9%), as well as unusual organisms such as Agrobacterium tumefaciens or Delftia tsuruhatensis. The overall CRI rate was 1.28 per 1,000 catheter days, or 0.47 per year.
The incidence of CRI using long-term, non-tunnelled central venous catheters in PH patients treated with iloprost is low. Uncommon, rare pathogens causing CRI were found in a substantial number of patients.
静脉注射前列环素疗法是毛细血管前性肺动脉高压（PH）患者治疗的基石之一。长期中心静脉导管会使患者面临感染并发症。
我们报告了苏黎世瑞士转诊中心通过非隧道式中心静脉导管接受伊洛前列素治疗的门诊PH患者的导管相关感染（CRI）发生率及细菌谱。
回顾了2000年5月至2012年6月期间15例接受静脉注射伊洛前列素治疗的PH患者的数据。
我们在4例患者中发现了11次由两种不同微生物引起的CRI。发现的病原体有短杆菌（55%）、藤黄微球菌（18%）、凝固酶阴性葡萄球菌（9%）和金黄色葡萄球菌（9%），以及诸如根癌农杆菌或鹤见德尔夫特菌等不常见微生物。总体CRI发生率为每1000导管日1.28次，或每年0.47次。
在接受伊洛前列素治疗的PH患者中，使用长期非隧道式中心静脉导管的CRI发生率较低。在大量患者中发现了导致CRI的不常见、罕见病原体。
