Department of Immunology, College of Medicine, Florida International University, Miami, FL 33199, USA.
Drug Discov Today. 2013 Nov;18(21-22):1074-80. doi: 10.1016/j.drudis.2013.06.010. Epub 2013 Jun 28.
Targeting across the blood-brain barrier (BBB) for treatment of central nervous system (CNS) diseases represents the most challenging aspect of, as well as one of the largest growing fields in, neuropharmaceutics. Combining nanotechnology with multiple imaging techniques has a unique role in the diagnosis and treatment (theranostics) of CNS disease. Such imaging techniques include anatomical imaging modalities, such as magnetic resonance imaging (MRI), ultrasound (US), X-ray computed tomography (CT), positron emission tomography (PET), single-photon emission computed tomography (SPECT), electron microscopy, autoradiography and optical imaging as well as thermal images. In this review, we summarize and discuss recent advances in formulations, current challenges and possible hypotheses concerning the use of such theranostics across the BBB.
针对血脑屏障(BBB)进行治疗,以治疗中枢神经系统(CNS)疾病,是神经药物学最具挑战性的方面之一,也是该领域最大的增长领域之一。将纳米技术与多种成像技术相结合,在中枢神经系统疾病的诊断和治疗(治疗学)方面具有独特的作用。此类成像技术包括解剖成像方式,如磁共振成像(MRI)、超声(US)、X 射线计算机断层扫描(CT)、正电子发射断层扫描(PET)、单光子发射计算机断层扫描(SPECT)、电子显微镜、放射自显影和光学成像以及热图像。在这篇综述中,我们总结并讨论了在 BBB 中使用这种治疗学方法的制剂、当前挑战和可能假设的最新进展。