Kaushik Ajeet, Jayant Rahul Dev, Sagar Vidya, Nair Madhavan
Florida International University, Institute of Neuroimmune Pharmacology, Herbert Wertheim College of Medicine, Center of Personalized Nanomedicine, Department of Immunology , Miami, FL-33199 , USA.
Expert Opin Drug Deliv. 2014 Oct;11(10):1635-46. doi: 10.1517/17425247.2014.933803. Epub 2014 Jul 2.
The development and design of personalized nanomedicine for better health quality is receiving great attention. In order to deliver and release a therapeutic concentration at the target site, novel nanocarriers (NCs) were designed, for example, magneto-electric (ME) which possess ideal properties of high drug loading, site-specificity and precise on-demand controlled drug delivery.
This review explores the potential of ME-NCs for on-demand and site-specific drug delivery and release for personalized therapeutics. The main features including effect of magnetism, improvement in drug loading, drug transport across blood-brain barriers and on-demand controlled release are also discussed. The future directions and possible impacts on upcoming nanomedicine are highlighted.
Numerous reports suggest that there is an urgent need to explore novel NC formulations for safe and targeted drug delivery and release at specific disease sites. The challenges of formulation lie in the development of NCs that improve biocompatibility and surface modifications for optimum drug loading/preservation/transmigration and tailoring of electrical-magnetic properties for on-demand drug release. Thus, the development of novel NCs is anticipated to overcome the problems of targeted delivery of therapeutic agents with desired precision that may lead to better patient compliance.
为提高健康质量而开发和设计个性化纳米药物正受到广泛关注。为了在靶位点递送和释放治疗浓度的药物，人们设计了新型纳米载体（NCs），例如磁电（ME）纳米载体，其具有高载药量、位点特异性和精确按需控制药物递送等理想特性。
本综述探讨了磁电纳米载体在个性化治疗中按需和位点特异性药物递送与释放方面的潜力。还讨论了其主要特性，包括磁性效应、载药量的提高、药物透过血脑屏障的运输以及按需控释。突出了未来方向以及对即将到来的纳米医学可能产生的影响。
众多报告表明，迫切需要探索新型纳米载体制剂，以在特定疾病位点实现安全且靶向的药物递送与释放。制剂面临的挑战在于开发能够提高生物相容性和进行表面修饰以实现最佳载药/保存/转运的纳米载体，以及为按需药物释放定制电磁特性。因此，预计新型纳米载体的开发将克服以所需精度进行治疗剂靶向递送的问题，这可能会提高患者的依从性。
