Zhang Yi-Min, Chen Ai-Lian, Tang Chun-zhi, Zhang Yu-qing, Yin Hai-bin, Chen Sheng-xin
Medical College of Jinan University, Guangzhou, China.
Zhen Ci Yan Jiu. 2013 Apr;38(2):158-62.
To observe the arousal effect of electroacupuncture (EA) stimulation of Baihui (GV 20), Shuigou (GV 26), etc. on severe craniocerebral injury patients.
A total of 90 cases of severe craniocerebral injury were randomly allocated to routine medication, naloxone and EA groups, with 30 cases in each group. For patients of the routine medication group, mild hypothermia therapy, medicines for dehydration, hormonal therapy, vascular dilation, cerebral nutrition supporting, anti-inflammation, etc. were given. For patients of the naloxone group, intravenous drip of naloxone 0.4 mg/kg in the first 3 days, 0.2 mg/kg for 7 days and 0. 1 mg/kg afterwards. For patients of the EA group, EA (1 Hz/50 Hz) was given for 30 min once daily. All the treatments were conducted once a day for 14 days. The Glasgow Coma Scale (GCS) and Glasgow Outcome Scale (GOS) were used for assessing the therapeutic effect.
In comparison with pre-treatment in each one of the routine medication, naloxone and EA groups, GCS scores were all obviously increased in the 3 groups following the treatment, and one month's follow-up (P<0. 05). The GCS scores of both naloxone and EA groups were significantly higher than those of the routine medication group (P<0.05). No significant difference was found between the naloxone group and EA group in GCS scores (P>0. 05). According to the GOS, one month's follow-up showed that of the three 30 cases in the routine medication, naloxone and EA groups, 6, 12 and 14 were improved, 8, 10 and 10 moderate handicap, 8, 3 and 2 severe handicap, 5, 3 and 2 vegetative state, and 3, 2 and 2 dead, with the arousal rates being 46. 66% , 73. 33% and 80. 00%, respectively. The therapeutic effects of both naloxone and EA groups were significantly superior to those of the routine medication group (P<0.05).
EA intervention at early stage can promote the recovery of neurological function, accelerate the consciousness from coma and improve the outcomes of patients with severe traumatic brain injury.
观察电针刺激百会（GV 20）、水沟（GV 26）等穴位对重型颅脑损伤患者的促醒作用。
将90例重型颅脑损伤患者随机分为常规药物治疗组、纳洛酮组和电针组，每组30例。常规药物治疗组患者给予亚低温治疗、脱水药物、激素治疗、扩血管、脑营养支持、抗炎等治疗。纳洛酮组患者于前3天静脉滴注纳洛酮0.4 mg/kg，7天内每天0.2 mg/kg，之后每天0.1 mg/kg。电针组患者给予电针（1 Hz/50 Hz），每天1次，每次30分钟。所有治疗均每天进行1次，共14天。采用格拉斯哥昏迷量表（GCS）和格拉斯哥预后量表（GOS）评估治疗效果。
常规药物治疗组、纳洛酮组和电针组治疗后GCS评分均较治疗前明显升高，且随访1个月时差异有统计学意义（P<0.05）。纳洛酮组和电针组的GCS评分均显著高于常规药物治疗组（P<0.05）。纳洛酮组和电针组GCS评分比较差异无统计学意义（P>0.05）。根据GOS，随访1个月时，常规药物治疗组、纳洛酮组和电针组的30例患者中，好转分别为6例、12例和14例，中度残疾分别为8例、10例和10例，重度残疾分别为8例、3例和2例，植物状态分别为5例、3例和2例，死亡分别为3例、2例和2例，促醒率分别为46.66%、73.33%和80.00%。纳洛酮组和电针组的治疗效果均显著优于常规药物治疗组（P<0.05）。
早期电针干预可促进重型颅脑损伤患者神经功能恢复，加速昏迷患者苏醒，改善患者预后。
