Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, Osaka, Japan.
Hepatol Res. 2014 Feb;44(2):149-58. doi: 10.1111/hepr.12194. Epub 2013 Aug 15.
The liver is the major organ for the metabolism of protein, fat and carbohydrate. A nutritional approach is required in the treatment of cirrhosis, which is frequently complicated with protein-energy malnutrition. Several advanced treatment approaches for hepatocellular carcinoma (HCC) have been established in the past decade. HCC is often complicated by cirrhosis, so treatment of the underlying liver diseases is also necessary to improve the prognosis. Branched-chain amino acid (BCAA) granules were developed originally for the treatment of hypoalbuminemia associated with decompensated cirrhosis. However, subsequent studies found various other pharmacological actions of this agent. We review the clinical significance of therapy using BCAA granules in patients receiving different treatment approaches for cirrhosis and HCC based on the published work as well as our own data.
肝脏是蛋白质、脂肪和碳水化合物代谢的主要器官。肝硬化常伴有蛋白质能量营养不良，需要营养治疗。在过去十年中，已经建立了几种治疗肝细胞癌 (HCC) 的先进方法。HCC 常伴有肝硬化，因此治疗基础肝病也是改善预后所必需的。支链氨基酸 (BCAA) 颗粒最初是为治疗失代偿期肝硬化相关的低白蛋白血症而开发的。然而，随后的研究发现了该药物的其他各种药理作用。我们根据已发表的工作和我们自己的数据，综述了不同治疗方法治疗肝硬化和 HCC 患者中使用 BCAA 颗粒治疗的临床意义。
