Dressel H
Institut für Arzneimittelwesen der DDR, Berlin.
Pharmazie. 1990 Mar;45(3):198-200.
Solutions containing bacterial lipopolysaccharides (P) and sodium nucleinate (NN) solutions filtered through cellulose asbestos filters became pyrogen free. But the filters, with respect to the pyrogenicity of these solutions, became earlier exhausted in case of NN than in case of P. A 12-min heating to 121 degrees C in the autoclave led to a significant lowering of pyrogenicity both in P- and in NN-solutions. After a 2-h heating in same conditions both P- and NN-solutions in the chosen ranges of concentration became pyrogen free.
含有细菌脂多糖（P）和经纤维素石棉滤器过滤的核酸钠（NN）溶液变得无热原。但是，就这些溶液的热原性而言，NN情况下滤器比P情况下更早耗尽。在高压灭菌器中于121℃加热12分钟导致P溶液和NN溶液的热原性均显著降低。在相同条件下加热2小时后，所选浓度范围内的P溶液和NN溶液均变得无热原。
