增强抗微生物药物的抗真菌活性的研究进展
Enhancement of the antifungal activity of antimicrobial drugs by Eugenia uniflora L.
机构信息
Laboratory of Microbiology and Molecular Biology, Regional University of Cariri, Crato, Brazil.
出版信息
J Med Food. 2013 Jul;16(7):669-71. doi: 10.1089/jmf.2012.0245. Epub 2013 Jul 2.
Abstract
Candidiasis is the most frequent infection by opportunistic fungi such as Candida albicans, Candida tropicalis, and Candida krusei. Ethanol extract from Eugenia uniflora was assayed, for its antifungal activity, either alone or combined with four selected chemotherapeutic antimicrobial agents, including anphotericin B, mebendazole, nistatin, and metronidazole against these strains. The obtained results indicated that the association of the extract of E. uniflora to metronidazole showed a potential antifungal activity against C. tropicalis. However, no synergistic activity against the other strains was observed, as observed when the extract was associated with the other, not enhancing their antifungal activity.
摘要
念珠菌病是最常见的机会性真菌感染，如白色念珠菌、热带念珠菌和克柔念珠菌。我们对茵芋的乙醇提取物进行了检测，评估其单独使用或与四种选定的化学治疗抗菌药物（两性霉素 B、甲苯咪唑、制霉菌素和甲硝唑）联合使用时对这些菌株的抗真菌活性。结果表明，茵芋提取物与甲硝唑联合使用对热带念珠菌具有潜在的抗真菌活性。然而，当提取物与其他药物联合使用时，并没有观察到对其他菌株的协同活性，也没有增强它们的抗真菌活性。
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2
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West Indian Med J. 2009 Mar;58(2):160-3.
3
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Indian J Med Res. 2010 Jan;131:106-8.
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