Kang Jun-Gu, Park Sang-Bum, Seo Min-Soo, Kim Hyung-Sik, Chae Joon-Seok, Kang Kyung-Sun
Department of Veterinary Internal Medicine,Department of Veterinary Public Health, College of Veterinary Medicine, and Research Institute for Veterinary Science, Seoul National University, Seoul 151-742, Korea.
J Vet Sci. 2013;14(3):367-71. doi: 10.4142/jvs.2013.14.3.367. Epub 2013 Jun 28.
Tendinitis of the superficial digital flexor tendon (SDFT) is a significant cause of lameness in horses; however, recent studies have shown that stem cells could be useful in veterinary regenerative medicine. Therefore, we isolated and characterized equine umbilical cord blood mesenchymal stem cells (eUCB-MSCs) from equine umbilical cord blood obtained from thoroughbred mares during the foaling period. Horses that had tendinitis of the SDFT were treated with eUCB-MSCs to confirm the therapeutic effect. After eUCB-MSCs transplantation, the core lesion in the SDFT was found to decrease. These results suggest that transplantation using eUCB-MSCs could be another source of cell treatment.
浅屈肌腱（SDFT）炎是马匹跛行的一个重要原因；然而，最近的研究表明干细胞在兽医再生医学中可能有用。因此，我们从纯种母马产驹期获得的马脐带血中分离并鉴定了马脐带血间充质干细胞（eUCB-MSCs）。对患有SDFT炎的马匹用eUCB-MSCs进行治疗以确认治疗效果。eUCB-MSCs移植后，发现SDFT中的核心病变有所减少。这些结果表明，使用eUCB-MSCs进行移植可能是细胞治疗的另一种来源。
