Maroto-Sánchez Beatriz, Valtueña Jara, Albers Ulrike, Benito Pedro J, González-Gross Marcela
Departamento de Salud y Rendimiento Humano, Facultad de Ciencias de la Actividad Física y del Deporte-INEF, Universidad Politécnica de Madrid, España.
Nutr Hosp. 2013 Mar-Apr;28(2):325-32. doi: 10.3305/nh.2013.28.2.6300.
High levels of homocysteine (Hcy) have been identified as a cardiovascular risk factor. Regarding physical exercise, the results are contradictory.
The aim of this study was to determine the influence of maximal intensity exercise and submaximal constant exercise on total serum homocysteine concentrations (tHcy) and other related parameters.
Ten physically active male subjects (mean age: 23.51 ± 1.84), performed two treadmill tests, a maximal test and a stable submaximal test at an intensity of 65% of maximal oxygen uptake (VO2max). Serum concentrations of tHcy, Folate, Vitamin B12 and creatinine were analysed before and after each test.
Significant increase in serum tHcy concentrations after the maximal (p < 0.05) and submaximal (p < 0.01) tests were observed. Folate and vitamin B12 concentrations also increased significantly after both tests (p < 0.05). Creatinine levels increased only after the maximal test (p < 0.001). A statistically significant inverse relationship was found between folate and tHcy concentrations (p < 0.05) at all the measurement points.
THcy levels increased significantly after acute exercise in both maximum and submaximal intensity exercises.
高同型半胱氨酸（Hcy）水平已被确认为心血管危险因素。关于体育锻炼，结果相互矛盾。
本研究旨在确定最大强度运动和次最大强度持续运动对血清总同型半胱氨酸浓度（tHcy）及其他相关参数的影响。
10名身体活跃的男性受试者（平均年龄：23.51±1.84岁）进行了两次跑步机测试，一次最大测试和一次强度为最大摄氧量（VO2max）65%的稳定次最大测试。在每次测试前后分析血清tHcy、叶酸、维生素B12和肌酐的浓度。
在最大测试（p<0.05）和次最大测试（p<0.01）后，观察到血清tHcy浓度显著增加。两次测试后叶酸和维生素B12浓度也显著增加（p<0.05）。仅在最大测试后肌酐水平升高（p<0.001）。在所有测量点，叶酸和tHcy浓度之间发现有统计学意义的负相关关系（p<0.05）。
在最大强度和次最大强度运动的急性运动后，tHcy水平均显著升高。
