ImFine Research Group, Department of Health and Human Performance. Faculty of Physical Activity and Sport Sciences (INEF), Universidad Politécnica de Madrid, Madrid, Spain.
LFE Research Group, Department of Health and Human Performance. Faculty of Physical Activity and Sport Sciences (INEF), Universidad Politécnica de Madrid, Madrid, Spain.
Amino Acids. 2019 Feb;51(2):193-204. doi: 10.1007/s00726-018-2655-y. Epub 2018 Sep 27.
This study aimed to assess the effect of rehydration during and after acute aerobic submaximal exercise on total homocysteine (tHcy) concentrations and related parameters in physically active adult males. Twenty trained males (29.4 ± 7.9 years old) completed four exercise tests: two without rehydration during exercise (NH1 and NH2), one with rehydration during exercise using water (H1) and one with rehydration during exercise using an isotonic sports drink (H2). After finishing the exercise tests, subjects followed a rehydration protocol for 2 h. Serum tHcy, vitamin B12, folate, creatine and creatinine were analysed before, after and at 2, 6 and 24 h after exercise. Data were analysed with and without correcting for haemoconcentration to assess the changes in tHcy related. The methylenetetrahydrofolate reductase (MTHFR) 677TT genotype was also analysed. THcy (uncorrected by haemoconcentration) increased significantly after exercise (P < 0.05) in the NH1 and NH2 tests [mean increase ± SD: 1.55 ± 0.33 (15.18%) and 1.76 ± 0.25 (17.69%) µmol/L, respectively], while no significant differences were found in the H1 and H2 tests [mean increase: 0.65 (6.29%) and 0.90 (8.69%) μmol/L, respectively]. The increase was partly due to haemoconcentration and partly due to the metabolism underlying acute exercise. THcy concentrations recovered to baseline after 24 h in all tests. In conclusion, adequate rehydration during acute aerobic exercise using either water or a sports drink maintains tHcy concentrations at baseline and for up to 2 h after exercise in physically active male adults and prevents further increases when compared to no rehydration.
这项研究旨在评估在急性有氧运动亚极量运动期间和之后进行补液对活跃成年男性总同型半胱氨酸（tHcy）浓度和相关参数的影响。20 名训练有素的男性（29.4±7.9 岁）完成了四项运动测试：两项在运动中不进行补液（NH1 和 NH2），一项在运动中使用水进行补液（H1），一项在运动中使用等渗运动饮料进行补液（H2）。运动测试结束后，受试者遵循 2 小时的补液方案。在运动前、运动后以及运动后 2、6 和 24 小时分析血清 tHcy、维生素 B12、叶酸、肌酸和肌酐。数据未经和经血液浓缩校正后进行分析，以评估与 tHcy 相关的变化。还分析了亚甲基四氢叶酸还原酶（MTHFR）677TT 基因型。未经血液浓缩校正的 tHcy（uncorrected by haemoconcentration）在 NH1 和 NH2 测试中显著升高（P<0.05）[平均增加±标准差：1.55±0.33（15.18%）和 1.76±0.25（17.69%）μmol/L]，而在 H1 和 H2 测试中没有发现显著差异[平均增加：0.65（6.29%）和 0.90（8.69%）μmol/L]。这种增加部分是由于血液浓缩，部分是由于急性运动导致的代谢变化。在所有测试中，tHcy 浓度在 24 小时后恢复到基线。总之，在活跃成年男性进行急性有氧运动时，使用水或运动饮料进行适当的补液可使 tHcy 浓度保持在基线水平，并在运动后 2 小时内保持稳定，与不补液相比可防止进一步升高。
