de Vries H, Bojarski J, Donker A A, Bakri A, Beyersbergen van Henegouwen G M
Center for Bio-Pharmaceutical Sciences, State University of Leiden, The Netherlands.
Toxicology. 1990 Jul;63(1):85-95. doi: 10.1016/0300-483x(90)90071-n.
Quindoxin (quinoxaline-1,4-dioxide), a former 'growth promoter' used in animal husbandry, has been taken from the market because of its photoallergic properties. Nowadays its derivatives olaquindox, carbadox and cyadox are frequently applied for the same purpose. Recent reports show that olaquindox too, can induce photoallergic skin reactions in stockmen. From the present investigation it appeared that all compounds mentioned, form a reactive oxaziridine upon exposure to light, just like many other imino-N-oxides. Photoreactivity with protein, which is considered as an important condition for a compound to be a potential photoallergen, was also studied. Quindoxin and olaquindox proved to meet this condition, as was expected. But carbadox and cyadox also react and were shown to be even more reactive towards human serum albumin.
喹乙醇（喹喔啉 -1,4-二氧化物），一种曾用于畜牧业的“生长促进剂”，因其光过敏特性已退出市场。如今其衍生物喹烯酮、卡巴氧和喹赛多也常用于同一目的。近期报道显示，喹烯酮也会在饲养员身上引发光过敏性皮肤反应。从目前的研究来看，上述所有化合物在光照下都会形成反应性恶嗪环乙烷，就像许多其他亚氨基 -N-氧化物一样。还研究了与蛋白质的光反应性，这被认为是一种化合物成为潜在光变应原的重要条件。正如预期的那样，喹乙醇和喹烯酮被证明符合这一条件。但卡巴氧和喹赛多也会发生反应，并且对人血清白蛋白的反应性更强。
