Cihák R, Vontorková M
Mutat Res. 1983 May-Jun;117(3-4):311-6. doi: 10.1016/0165-1218(83)90130-1.
The clastogenicity of the growth-promoting agents, carbadox, olaquindox and cyadox, was examined by the metaphase analysis of chromosome aberrations in bone marrow of mice. The agents were administered by a stomach tube to male ICR mice 24 h before they were killed. Single-dose levels were 50, 100 and 200 mg/kg for carbadox; 200, 400, 600 and 800 mg/kg for olaquindox; and 400, 800 and 1200 mg/kg for cyadox. Carbadox was the most active; it induced chromosome aberrations even at a dose of 100 mg/kg. Olaquindox had about the same activity at a dose of 800 mg/kg. No chromosome-damaging effect of cyadox was observed even at a dose of 1200 mg/kg.
通过对小鼠骨髓细胞染色体畸变的中期分析，研究了促生长剂卡巴氧、喹乙醇和喹赛多的致断裂性。在处死雄性ICR小鼠前24小时，通过胃管给它们施用这些药剂。卡巴氧的单剂量水平分别为50、100和200毫克/千克；喹乙醇的单剂量水平分别为200、400、600和800毫克/千克；喹赛多的单剂量水平分别为400、800和1200毫克/千克。卡巴氧活性最强；即使剂量为100毫克/千克时也能诱导染色体畸变。喹乙醇在剂量为800毫克/千克时具有大致相同的活性。即使剂量为1200毫克/千克时，也未观察到喹赛多对染色体的损伤作用。
