Department of Nutrition, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Diabet Med. 2013 Dec;30(12):1477-81. doi: 10.1111/dme.12273. Epub 2013 Jul 27.
Vitamin D deficiency is considered as a risk factor in cardiometabolic disorders, including cardiovascular diseases, hypertension and Type 2 diabetes mellitus. We have investigated the effect of vitamin D3 supplementation on glucose homeostasis in healthy overweight and obese women.
In a double-blind randomized placebo-controlled clinical trial, 77 healthy overweight or obese women (mean age 38 ± 8 years; BMI 29.9 ± 4.2 kg/m(2)) were randomly assigned to the vitamin D3 group (25 μg/day as cholecalciferol tablets) or the placebo group. Selected anthropometric indices, glucose, insulin, HbA(1c) and homeostasis model assessment of insulin resistance at baseline and after 12 weeks were measured. Dietary intakes using 24-h food recall and food frequency questionnaires were assessed. Physical activity was assessed by the International Physical Activity Questionnaire. Adjusted mean differences were calculated using analysis of covariance. Correlation coefficients were calculated by Pearson's analysis.
Mean fasting blood glucose concentrations declined in the vitamin D3 and placebo groups (-0.28 ± 0.4 vs. -0.65 ± 0.4 mmol/l, P < 0.001) and the mean percentage of HbA(1c) was decreased (-13 ± 18 vs. -19 ± 17 mmol/l, P = 0.06) in both groups, respectively. Mean 25-hydroxyvitamin D concentrations increased in the vitamin D3 and placebo groups (38.2 ± 32 vs. 4.6 ± 14 nmol/l, P < 0.001), respectively. There was a significant correlation between HbA(1c) and 25-hydroxyvitamin D concentrations (r = -0.271; P = 0.018).
The results indicate that the vitamin D3 supplement of 25 μg/day had no beneficial effect on glycaemic indices in healthy overweight or obese women.
维生素 D 缺乏被认为是心血管疾病、高血压和 2 型糖尿病等代谢紊乱的一个危险因素。我们研究了维生素 D3 补充对健康超重和肥胖女性葡萄糖稳态的影响。
在一项双盲、随机、安慰剂对照的临床试验中，77 名健康超重或肥胖女性（平均年龄 38 ± 8 岁；BMI 29.9 ± 4.2 kg/m2）被随机分配到维生素 D3 组（每天 25 μg，作为胆钙化醇片）或安慰剂组。在基线和 12 周后测量了选定的人体测量指标、血糖、胰岛素、HbA1c 和稳态模型评估的胰岛素抵抗。使用 24 小时食物回忆和食物频率问卷评估饮食摄入量。使用国际体力活动问卷评估体力活动。使用协方差分析计算调整后的平均差异。使用 Pearson 分析计算相关系数。
维生素 D3 组和安慰剂组的空腹血糖浓度分别下降（-0.28 ± 0.4 对-0.65 ± 0.4 mmol/L，P < 0.001），HbA1c 的平均百分比分别下降（-13 ± 18 对-19 ± 17 mmol/L，P = 0.06）。维生素 D3 组和安慰剂组的 25-羟维生素 D 浓度分别升高（38.2 ± 32 对 4.6 ± 14 nmol/L，P < 0.001）。HbA1c 与 25-羟维生素 D 浓度之间存在显著相关性（r = -0.271；P = 0.018）。
结果表明，每天补充 25 μg 维生素 D3 对健康超重或肥胖女性的血糖指标没有有益影响。
