Department of Nutrition, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Nutr J. 2012 Sep 22;11:78. doi: 10.1186/1475-2891-11-78.
Vitamin D concentrations are linked to body composition indices, particularly body fat mass. Relationships between hypovitaminosis D and obesity, described by both BMI and waist circumference, have been mentioned. We have investigated the effect of a 12-week vitamin D3 supplementation on anthropometric indices in healthy overweight and obese women.
In a double-blind, randomized, placebo-controlled, parallel-group trial, seventy-seven participants (age 38 ± 8.1 years, BMI 29.8 ± 4.1 kg/m²) were randomly allocated into two groups: vitamin D (25 μg per day as cholecalciferol) and placebo (25 μg per day as lactose) for 12 weeks. Body weight, height, waist, hip, fat mass, 25(OH) D, iPTH, and dietary intakes were measured before and after the intervention.
Serum 25(OH)D significantly increased in the vitamin D group compared to the placebo group (38.2 ± 32.7 nmol/L vs. 4.6 ± 14.8 nmol/L; P<0.001) and serum iPTH concentrations were decreased by vitamin D3 supplementation (-0.26 ± 0.57 pmol/L vs. 0.27 ± 0.56 pmol/L; P<0.001). Supplementation with vitamin D3 caused a statistically significant decrease in body fat mass in the vitamin D group compared to the placebo group (-2.7 ± 2.1 kg vs. -0.47 ± 2.1 kg; P<0.001). However, body weight and waist circumference did not change significantly in both groups. A significant reverse correlation between changes in serum 25(OH) D concentrations and body fat mass was observed (r = -0.319, P = 0.005).
Among healthy overweight and obese women, increasing 25(OH) D concentrations by vitamin D3 supplementation led to body fat mass reduction.
维生素 D 浓度与身体成分指数有关，尤其是体脂肪量。描述了维生素 D 缺乏症与肥胖之间的关系，无论是通过 BMI 还是腰围。我们研究了 12 周维生素 D3 补充对健康超重和肥胖女性的人体测量指数的影响。
在一项双盲、随机、安慰剂对照、平行组试验中，77 名参与者（年龄 38 ± 8.1 岁，BMI 29.8 ± 4.1 kg/m²）被随机分为两组：维生素 D（每天 25 μg 作为胆钙化醇）和安慰剂（每天 25 μg 作为乳糖），干预时间为 12 周。在干预前后测量了体重、身高、腰围、臀围、体脂肪量、25（OH）D、iPTH 和饮食摄入量。
与安慰剂组相比，维生素 D 组血清 25（OH）D 显著增加（38.2 ± 32.7 nmol/L 比 4.6 ± 14.8 nmol/L；P<0.001），血清 iPTH 浓度因维生素 D3 补充而降低（-0.26 ± 0.57 pmol/L 比 0.27 ± 0.56 pmol/L；P<0.001）。与安慰剂组相比，维生素 D 组补充维生素 D3 可使体脂肪量显著减少（-2.7 ± 2.1 kg 比-0.47 ± 2.1 kg；P<0.001）。然而，两组的体重和腰围均无明显变化。观察到血清 25（OH）D 浓度变化与体脂肪量之间存在显著的反向相关性（r = -0.319，P = 0.005）。
在健康超重和肥胖女性中，维生素 D3 补充可增加 25（OH）D 浓度，从而减少体脂肪量。
