Department of Public Health, and Department of Anesthesiology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Department of Obstetrics and Gynaecology, Woman's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Eur J Clin Nutr. 2019 Jun;73(6):816-834. doi: 10.1038/s41430-019-0417-x. Epub 2019 Mar 14.
BACKGROUND/OBJECTIVES: Optimal doses of vitamin D (VitD) supplement in different populations are unclear. We aim to evaluate the relationship between VitD supplementation and post-intervention serum 25-hydroxyvitamin D [25(OH)D] concentration, to provide a recommended dosage of VitD for achieving an optimal 25(OH)D concentration for different populations.
SUBJECTS/METHODS: Literature search was conducted in Embase, etc. Randomized controlled trials about VitD supplemental intakes and their effect on 25(OH)D concentration were enrolled. The effect on 25(OH)D concentration between different supplementation doses in each population group was compared by meta-analysis. Multivariate meta-regression model is utilized to establish reference intake dosage of VitD.
A total of 136 articles were included about children (3-17 years), adults (18-64 years), postmenopausal women, the elderly ( >64 years), pregnant, or lactating women. Overall, intervention groups obtained higher 25(OH)D concentration than controls and there was obvious dose-response effect between intake dose and 25(OH)D concentration. Baseline 25(OH)D concentration and age were significant indicators for 25(OH)D concentration. To reach sufficient 25(OH)D concentration (75 nmol/L), the recommended VitD supplemental intakes was 1340 and 2250 IU/day for children and pregnant women, 2519 and 797 IU/day for European adults aged 18-64 and 65-85 years, 729, 2026, and 1229 IU/day for adults in North America, Asia and Middle East and Africa, respectively.
Regional- and age-specific recommended dosages of VitD supplements for population to achieve optimal 25(OH)D concentrations have been suggested.
背景/目的：不同人群中维生素 D（VitD）补充的最佳剂量尚不清楚。我们旨在评估 VitD 补充与干预后血清 25-羟维生素 D [25(OH)D]浓度之间的关系，为不同人群达到最佳 25(OH)D 浓度提供 VitD 的推荐剂量。
受试者/方法：在 Embase 等数据库中进行文献检索，纳入关于 VitD 补充摄入量及其对 25(OH)D 浓度影响的随机对照试验。通过荟萃分析比较了每个人群组中不同补充剂量对 25(OH)D 浓度的影响。利用多变量荟萃回归模型建立 VitD 的参考摄入量。
共纳入了 136 篇关于儿童（3-17 岁）、成人（18-64 岁）、绝经后妇女、老年人（>64 岁）、孕妇或哺乳期妇女的文章。总体而言，干预组的 25(OH)D 浓度高于对照组，且摄入量与 25(OH)D 浓度之间存在明显的剂量反应关系。基线 25(OH)D 浓度和年龄是 25(OH)D 浓度的重要指标。为达到足够的 25(OH)D 浓度（75nmol/L），推荐的 VitD 补充摄入量分别为儿童和孕妇 1340 和 2250IU/天，欧洲 18-64 岁和 65-85 岁成年人 2519 和 797IU/天，北美、亚洲和中东和非洲的成年人分别为 729、2026 和 1229IU/天。
建议针对不同人群制定区域和年龄特异性的 VitD 补充剂推荐剂量，以达到最佳 25(OH)D 浓度。
