Lozano Sánchez F S, Sánchez Nevarez I, González-Porras J R, Marinello Roura J, Escudero Rodríguez J R, Díaz Sánchez S, Carrasco Carrasco E
Department of Angiology and Vascular Surgery, IBSAL Salamanca University Hospital, Salamanca, Spain.
Int Angiol. 2013 Aug;32(4):433-41.
Chronic venous disease (CVD) is a well-defined and known disorder which impact on related-health quality of life (QoL). However, individuals factors which determinate quality of life on CVD are not well defined. The purposes of this study were to describe the QoL in patients with CVD and examine socio-demographical and clinical factors which influence QoL METHODS: One thousand five hundred sixty patients with CVD were evaluated. We calculated for each patient two disease-specific severity scores: The "C" grade (clinical) of the CEAP classification and the Venous Clinical Severity Score (VCSS). Additionally, two QoL questionnaires were recorded: Short-Form Health Survey (SF-12) and Chronic Lower Limb Venous Insufficiency Questionnaire (CIVIQ-20). Two multivariate logistic regression analyses (SF-12 and CIVIQ-20 model) were conducted to determine whether demographic and clinical variables were independently associated with QoL.
Both QoL questionnaires indicated that the QoL decreased significantly (P<0.05) as the C grade of CEAP increased. Each increase of 0.10 in VCSS score represented 2% worsening in QoL as measured by CIVIQ-20. Three factors were strongly associated with poor QoL on SF-12: increasing age, prior superficial venous thrombosis (SVT) or prior deep venous thrombosis. In the specific disease CIVIQ-20 questionnaire three factors (higher age, prior SVT and higher weight) were strongly associated with decrease QoL.
Increasing disease severity by VCSS is associated with reductions in QoL. Subgroup analysis indicates that there are several significant individual determinants of worsening QoL.
慢性静脉疾病（CVD）是一种明确且已知的疾病，会影响相关的健康生活质量（QoL）。然而，决定CVD患者生活质量的个体因素尚未明确界定。本研究的目的是描述CVD患者的生活质量，并研究影响生活质量的社会人口统计学和临床因素。方法：对1560例CVD患者进行评估。我们为每位患者计算了两个疾病特异性严重程度评分：CEAP分类的“C”级（临床）和静脉临床严重程度评分（VCSS）。此外，记录了两份生活质量问卷：简短健康调查问卷（SF - 12）和慢性下肢静脉功能不全问卷（CIVIQ - 20）。进行了两项多因素逻辑回归分析（SF - 12和CIVIQ - 20模型），以确定人口统计学和临床变量是否与生活质量独立相关。
两份生活质量问卷均表明，随着CEAP的C级增加，生活质量显著下降（P<0.05）。根据CIVIQ - 20测量，VCSS评分每增加0.10，生活质量恶化2%。SF - 12显示有三个因素与生活质量差密切相关：年龄增加、既往浅表静脉血栓形成（SVT）或既往深静脉血栓形成。在特定疾病的CIVIQ - 20问卷中，三个因素（年龄较大、既往SVT和体重较重）与生活质量下降密切相关。
VCSS所反映的疾病严重程度增加与生活质量降低相关。亚组分析表明，有几个显著的个体因素会导致生活质量恶化。
