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自膨式 Y 型支架治疗中央气道狭窄:回顾性分析。

Self-expanding Y stents in the treatment of central airway stenosis: a retrospective analysis.

机构信息

Pneumology and Critical Care Medicine, Thoraxklinik at the University of Heidelberg, Heidelberg Amalienstr, 5 69126 Heidelberg, Germany.

出版信息

Ther Adv Respir Dis. 2013 Oct;7(5):255-63. doi: 10.1177/1753465813489766. Epub 2013 Jul 2.

Abstract

BACKGROUND

Central airway obstruction (CAO) is a life-threatening situation. Stent insertion re-establishes patency of the central airways. Self-expanding metallic Y stents have been available since 2005, widening the spectrum of interventional bronchoscopic techniques.

METHODS

Retrospective analysis of all patients treated for CAO with a self-expanding metallic Y stent at the Thoraxklinik Heidelberg between May 2005 and January 2009.

RESULTS

A total of 43 patients aged 26-81 had a metallic Y stent inserted endoscopically for the treatment of CAO; 39 of these patients (90.7%) had CAO due to malignant disease, four patients (9.3%) due to benign disease. In all 43 patients, the Y stent was deployed without any complications. A longitudinal follow up was possible in 32 of the 43 patients. The stents remained in situ for an average of 107.1 days (range 1-640 days). In 29 patients with malignant CAO the stenosis was successfully overcome with a Y stent; 11 of these patients died within 6 weeks following stent insertion. On follow up the remaining 18 patients showed immediate improvement of dyspnoea. Eight out of the 18 patients (44.4%) tolerated the stent without problems, two (11.1%) required further stenting, six (33.3%) had complications such as increased secretions, cough, dyspnoea or granulation tissue formation. The stent was removed in one patient (5.6%) due to increased secretions, and in another (5.6%) as the stent was no longer required due to successful tumour-specific therapy.

CONCLUSION

Placement of Y stents in symptomatic CAO allows for quick relief of symptoms. Severe complications are rare. Stent removal is possible after successful treatment of the primary tumour. However, the prognostic indicator for survival is the underlying malignancy.

摘要

背景

中央气道阻塞(CAO)是一种危及生命的情况。支架置入术可重建中央气道的通畅性。自 2005 年以来,自膨式金属 Y 支架已被应用,拓宽了介入性支气管镜技术的范围。

方法

回顾性分析 2005 年 5 月至 2009 年 1 月在海德堡胸科医院接受自膨式金属 Y 支架治疗的所有 CAO 患者。

结果

共 43 例年龄 26-81 岁的患者因 CAO 接受内镜下自膨式金属 Y 支架置入术,其中 39 例(90.7%)为恶性疾病所致,4 例(9.3%)为良性疾病所致。在所有 43 例患者中,Y 支架均成功植入,无任何并发症。43 例患者中有 32 例可进行纵向随访。支架平均留置 107.1 天(1-640 天)。在 29 例恶性 CAO 患者中,Y 支架成功克服狭窄;其中 11 例患者在支架置入后 6 周内死亡。随访时,其余 18 例患者呼吸困难立即得到改善。18 例患者中有 8 例(44.4%)无支架相关问题,2 例(11.1%)需要进一步支架置入,6 例(33.3%)出现分泌物增加、咳嗽、呼吸困难或肉芽组织形成等并发症。1 例患者(5.6%)因分泌物增加而取出支架,另 1 例(5.6%)因肿瘤特异性治疗成功而无需支架。

结论

在有症状的 CAO 中放置 Y 支架可迅速缓解症状。严重并发症罕见。在原发肿瘤成功治疗后可取出支架。然而,生存的预后指标是基础恶性肿瘤。

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