Trombelli L, Farina R
Research Centre for the Study of Periodontal and Peri-implant Diseases University of Ferrara, Ferrara, Italy -
Minerva Stomatol. 2013 Jun;62(6):207-34.
An individual variation in the gingival inflammatory response to the dental biofilm has been demonstrated. This variability can be observed between individuals with neither quantitative nor qualitative differences in plaque accumulation. The reported significant differences in gingival inflammatory response under quantitatively and/or qualitatively almost identical bacterial challenge suggest that the gingival response to plaque accumulation may be an individual trait, possibly genetic in origin. The most recent classification of periodontal diseases acknowledges that the clinical expression of plaque-induced gingival inflammation can be substantially modified by systemic factors, either inherent to the host or related to environmental influences. The aim of the present literature review is to describe (i) the factors influencing the development of plaque-induced gingivitis as well as (ii) those metabolic, environmental and systemic factors which have a direct impact on the etiopathogenetic pathway of plaque-induced gingivitis, thus altering the nature or course of the gingival inflammatory response to dental biofilm.
牙龈对牙菌斑的炎症反应存在个体差异，这一点已得到证实。在菌斑积聚方面既无数量差异也无质量差异的个体之间，也能观察到这种变异性。据报道，在定量和/或定性几乎相同的细菌攻击下，牙龈炎症反应存在显著差异，这表明牙龈对菌斑积聚的反应可能是一种个体特征，其起源可能与遗传有关。最新的牙周疾病分类承认，菌斑诱导的牙龈炎症的临床表现会受到全身因素的显著影响，这些因素要么是宿主固有的，要么与环境影响有关。本文献综述的目的是描述：（i）影响菌斑性牙龈炎发展的因素，以及（ii）那些对菌斑性牙龈炎的病因发病途径有直接影响的代谢、环境和全身因素，从而改变牙龈对牙菌斑炎症反应的性质或进程。
