French Agency for Food, Environmental and Occupational Health & Safety (ANSES), Nancy; Laboratory for Rabies and Wildlife, WHO Collaborating Centre for Research and Management in Zoonoses Control, OIE Reference Laboratory for Rabies, European Union Reference Laboratory for Rabies, European Union Reference Institute for Rabies Serology, Technopôle Agricole et Vétérinaire, Malzéville, France.
National Diagnostic Research Veterinary Medical Institute, National Reference Laboratory of Rabies and monitoring the effectiveness of the vaccination, Sofia, Bulgaria.
Epidemiol Infect. 2014 Apr;142(4):871-7. doi: 10.1017/S0950268813001556. Epub 2013 Jul 5.
A health emergency situation occurred in Bulgaria in 2007 when positive rabies cases were notified in Sofia district in the central-western part of the country, suggesting a southward spread of the disease for the first time in the last 10 years. Phylogenetic analysis on 49 isolates sampled between 2009 and 2011 showed, for the first time, evidence of the existence of NEE and D clustered lineages in Bulgaria. Their geographical distribution clearly reveals the permeability of natural barriers, as already suggested by the disease spread that occurred across the Balkan mountain range in 2007. The monitoring and passive surveillance programmes conducted since the first 2009 oral vaccination campaign, the spatio-temporal evolution of the disease in the country since 2007, and the need for further investigation of the role of jackals in virus dispersion are discussed.
2007 年保加利亚发生公共卫生紧急事件，该国中西部索非亚地区出现狂犬病确诊病例，这是该国十年来首次发现疾病向南传播。2009 年至 2011 年间采集的 49 个分离株的系统进化分析首次表明，NEE 和 D 聚类谱系在保加利亚存在。其地理分布清楚地显示了自然屏障的可渗透性，正如 2007 年巴尔干山脉发生的疾病传播所表明的那样。自 2009 年首次口服疫苗接种运动以来，一直在进行监测和被动监测计划，自 2007 年以来疾病在该国的时空演变，以及进一步调查豺在病毒传播中的作用的必要性，都进行了讨论。
