不同饮食对腐食酪螨种群的影响以及大蒜对其免疫紊乱的改善作用
Effect of different diets on Tyrophagus putrescentiae population and amelioration of their immunological disorder by garlic.
作者信息
Abdel-Salam Bahaa K A
机构信息
Zoology Department, Faculty of Science, 61519 El-Minia University, El-Minia, Egypt; Biology Department, Deanship of PreparatoryYear, Shaqra University, 11961 Shaqra, Saudi Arabia.
出版信息
Allergol Immunopathol (Madr). 2014 Sep-Oct;42(5):459-64. doi: 10.1016/j.aller.2013.05.002. Epub 2013 Jul 2.
BACKGROUND
The storage mite, Tyrophagus putrescentiae, detected in the samples collected from stored products and house dust, is one of the major causes of allergic disorders.
OBJECTIVE
The purpose of this study was to ameliorate the T. putrescentiae faeces allergic immunological disorder by garlic.
METHODS
Albino experimental rats were classified into control, inhaled and treated groups. Mass rearing of T. putrescentiae on different diets, and ELISA of some cytokines and IgE techniques were used.
RESULTS
The results obtained showed the highest population of T. putrescentiae reared in four from thirteen tested diets. In addition, significantly higher serum levels of INF-γ and IgE were found in rats treated with faeces than the other groups; especially the garlic-treated group. In contrast, IL-4 was lower in faeces-treated rats than the others; however, the control group had the highest level of IL-4. Statistical analysis of data showed a significant difference between the garlic-treated group and either control or faeces-treated groups (P<0.05).
CONCLUSIONS
The population of T. putrescentiae mites peaked in four from thirteen tested diets. The immunological disorder caused by repeated exposure to T. putrescentiae faeces might be modulated by garlic.
背景
在从储存产品和室内灰尘中采集的样本中检测到的腐食酪螨是过敏性疾病的主要病因之一。
目的
本研究旨在通过大蒜改善腐食酪螨粪便过敏性免疫紊乱。
方法
将白化实验大鼠分为对照组、吸入组和治疗组。采用在不同饲料上大量饲养腐食酪螨以及一些细胞因子和IgE技术的酶联免疫吸附测定法。
结果
所得结果表明，在13种受试饲料中的4种上饲养的腐食酪螨数量最多。此外，粪便处理组大鼠的血清INF-γ和IgE水平显著高于其他组；尤其是大蒜处理组。相比之下，粪便处理组大鼠的IL-4水平低于其他组；然而，对照组的IL-4水平最高。数据的统计分析表明，大蒜处理组与对照组或粪便处理组之间存在显著差异（P<0.05）。
结论
在13种受试饲料中的4种上，腐食酪螨数量达到峰值。反复接触腐食酪螨粪便引起的免疫紊乱可能会受到大蒜的调节作用。
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