ICL 在 S 期内外修复的差异。
The differences between ICL repair during and outside of S phase.
机构信息
Department of Genetics and Development, Institute for Cancer Genetics, Columbia University, New York, NY 10032, USA.
出版信息
Trends Biochem Sci. 2013 Aug;38(8):386-93. doi: 10.1016/j.tibs.2013.05.004. Epub 2013 Jul 3.
Abstract
DNA interstrand crosslinks (ICLs) are complex lesions that block essential DNA transactions including DNA replication, recombination, and RNA transcription. Naturally occurring ICLs are rare, yet these lesions are the major cause of toxicity following treatment with several classes of crosslinking cancer chemotherapeutic drugs. ICLs are repaired during and outside of S phase by pathways with overlapping as well as distinct features. Here, we discuss some recent insights into the mechanisms of replication-dependent and replication-independent repair of ICLs with special emphasis on the differences between these repair pathways.
摘要
DNA 链间交联 (ICLs) 是一种复杂的损伤，可阻断包括 DNA 复制、重组和 RNA 转录在内的基本 DNA 转导。天然产生的 ICL 很少见，但这些损伤是几种交联型癌症化疗药物治疗后毒性的主要原因。在 S 期内外，通过具有重叠和独特特征的途径修复 ICL。在这里，我们讨论了一些关于复制依赖性和非复制依赖性 ICL 修复机制的最新见解，特别强调了这些修复途径之间的差异。
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