Reversal of protamine-induced catastrophic pulmonary vasoconstriction by prostaglandin E1.
作者信息
Whitman G J, Martel D, Weiss M, Pochanapring A, See W M, Hopeman A, Harken A H, Dauber I M
机构信息
Department of Surgery, University of Colorado, Denver.
出版信息
Ann Thorac Surg. 1990 Aug;50(2):303-5. doi: 10.1016/0003-4975(90)90758-x.
PMID:2383122
Abstract
A case of catastrophic pulmonary vasoconstriction occurring after cardiopulmonary bypass after protamine reversal of heparin treated successfully with intravenous prostaglandin E1 is reported. Systemic hypotension was counteracted by epinephrine given through the left atrium. Protamine-heparin reactions are reviewed and a pathophysiological mechanism for the beneficial effect seen with prostaglandin E1 is proposed.
摘要
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