Whitman G J, Martel D, Weiss M, Pochanapring A, See W M, Hopeman A, Harken A H, Dauber I M
Department of Surgery, University of Colorado, Denver.
Ann Thorac Surg. 1990 Aug;50(2):303-5. doi: 10.1016/0003-4975(90)90758-x.
A case of catastrophic pulmonary vasoconstriction occurring after cardiopulmonary bypass after protamine reversal of heparin treated successfully with intravenous prostaglandin E1 is reported. Systemic hypotension was counteracted by epinephrine given through the left atrium. Protamine-heparin reactions are reviewed and a pathophysiological mechanism for the beneficial effect seen with prostaglandin E1 is proposed.
报道了1例在肝素经鱼精蛋白逆转后体外循环期间发生灾难性肺血管收缩的病例，该病例经静脉注射前列腺素E1成功治疗。通过经左心房给予肾上腺素来对抗全身性低血压。对鱼精蛋白-肝素反应进行了综述，并提出了前列腺素E1产生有益作用的病理生理机制。
