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耐药还是适应?在没有选择压力的情况下,“戊二醛耐药”铜绿假单胞菌分离株的易感性如何?

Resistance or adaptation? How susceptible is a 'glutaraldehyde-resistant' Pseudomonas aeruginosa isolate in the absence of selection pressure?

机构信息

Bode Science Center, Bode Chemie GmbH, Hamburg, Germany; Institute for Hygiene and Environmental Medicine, Ernst-Moritz-Arndt University, Greifswald, Germany.

出版信息

J Hosp Infect. 2013 Aug;84(4):316-8. doi: 10.1016/j.jhin.2013.05.010. Epub 2013 Jul 5.

Abstract

The activities of glutaraldehyde solution and an instrument disinfectant based on glutaraldehyde on a Pseudomonas aeruginosa isolate with reduced susceptibility to glutaraldehyde after the first and fifth passages were determined using three concentrations and temperatures. No significant difference was found between the first and fifth passages so phenotypic adaptation is unlikely.

摘要

采用三种浓度和温度,测定了戊二醛溶液和一种戊二醛为基础的器械消毒剂对经过第一和第五次传代后对戊二醛敏感性降低的铜绿假单胞菌分离株的活性。在第一和第五次传代之间未发现显著差异,因此不太可能发生表型适应。

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