Pakistan Council of Scientific and Industrial Research Laboratories Complex, Karachi, Sindh, Pakistan.
Spectrochim Acta A Mol Biomol Spectrosc. 2013 Nov;115:51-6. doi: 10.1016/j.saa.2013.06.032. Epub 2013 Jun 19.
A quick and reliable analytical method for the quantitative assessment of cefixime in orally administered pharmaceutical formulations is developed by using diamond cell attenuated total reflectance (ATR) Fourier transform infrared (FT-IR) spectroscopy as an easy procedure for quality control laboratories. The standards for calibration were prepared in aqueous medium ranging from 350 to 6000mg/kg. The calibration model was developed based on partial least square (PLS) using finger print region of FT-IR spectrum in the range from 1485 to 887cm(-1). Excellent coefficient of determination (R(2)) was achieved as high as 0.99976 with root mean square error of 44.8 for calibration. The application of diamond cell (smart accessory) ATR FT-IR proves a reliable determination of cefixime in pharmaceutical formulations to assess the quality of the final product.
建立了一种快速可靠的分析方法，用于定量评估口服药物制剂中的头孢克肟，方法是使用金刚石池衰减全反射（ATR）傅里叶变换红外（FT-IR）光谱作为质量控制实验室的简易程序。校准标准品在水介质中制备，浓度范围为 350 至 6000mg/kg。校准模型是基于傅里叶变换红外光谱指纹区（1485 至 887cm(-1)）的偏最小二乘（PLS）建立的。校准的决定系数（R(2)）高达 0.99976，均方根误差为 44.8。金刚石池（智能附件）ATR FT-IR 的应用证明了它可用于可靠地测定药物制剂中的头孢克肟，以评估最终产品的质量。
