Khanna O P, Elkouss G, Heber D, Gonick P
Urology. 1975 Jul;6(1):49-51. doi: 10.1016/0090-4295(75)90592-0.
Our study of the pharmacodynamics of imipramine hydrochloride of the female canine lower urinary tract indicates the primary mode of action to be the stimulation of alpha adrenergic neuroreceptors in the bladder neck and urethra. This stimulation results in increased resting urethral pressure, adequate sphincter closure, possibly an increase in the bladder capacity and efficient urinary control. Imipramine had no anticholinergic effect on the bladder and the urethra. It also appears unlikely that in enuretic patients imipramine acts by central augmentation of the adrenergic system. No change was noticed in the intravesical or arterial pressures.
我们对雌性犬类下尿路盐酸丙咪嗪药效学的研究表明，其主要作用方式是刺激膀胱颈和尿道中的α肾上腺素能神经受体。这种刺激会导致静息尿道压力升高、括约肌充分闭合，膀胱容量可能增加以及实现有效的尿液控制。丙咪嗪对膀胱和尿道没有抗胆碱能作用。遗尿患者中丙咪嗪似乎也不太可能通过中枢增强肾上腺素能系统起作用。膀胱内压或动脉压未发现变化。
