Khanna O P
Urology. 1976 Oct;8(4):316-28. doi: 10.1016/0090-4295(76)90483-0.
The clinical use of various pharmacologic agents in problems of micturition is based on the new concepts of intrinsic urethrovesical innervation, presence and regional predominance of autonomic neuroreceptors, and experimental evidence of the effects of various drugs on the bladder and the urethra. A new concept, relating to the processes that control bladder filling and emptying, is coming into being and replacing the traditional concept based on anatomic grounds alone. On the basis of the published data, and from personal experience both experimental and clinical, pharmacologic agents singly or in combination can be effectively and safely used in various problems of micturition such as incontinence (enuresis, stress incontinence in women, postprostatectomy, urgency incontinence), and functional outflow obstruction caused by neurologic or non-neurologic disease processes.
各种药物制剂在排尿问题中的临床应用是基于尿道膀胱内在神经支配、自主神经受体的存在及区域优势以及各种药物对膀胱和尿道作用的实验证据等新概念。一个与控制膀胱充盈和排空过程相关的新概念正在形成，并正在取代仅基于解剖学依据的传统概念。根据已发表的数据以及个人的实验和临床经验，药物制剂单独或联合使用可有效且安全地用于各种排尿问题，如尿失禁（遗尿、女性压力性尿失禁、前列腺切除术后、急迫性尿失禁）以及由神经或非神经疾病过程引起的功能性流出道梗阻。
