Watanabe Y, Kawasaki K, Miki N, Kuo C H
Department of Pharmacology, Kanazawa University, Japan.
Biochem Biophys Res Commun. 1990 Jul 31;170(2):951-6. doi: 10.1016/0006-291x(90)92183-z.
We have isolated and sequenced a human gene encoding photoreceptor cell-specific MEKA protein. The protein coding region was separated into three exons, which encoded 246 amino acid residues with a molecular weight of 28,311. The coding region of the human gene exhibited the homologies of 90.7% nucleotides and 88.5% amino acids with those of the bovine cDNA. Southern blot analysis revealed that the human MEKA gene has a single copy number. However, the anti-bovine MEKA stained both rod and cone photoreceptor cells in the human retina.
