系统性红斑狼疮患者视网膜静脉阻塞的风险：一项基于人群的队列研究。
Risk of retinal vein occlusion in patients with systemic lupus erythematosus: a population-based cohort study.
机构信息
Department of Ophthalmology, Chi Mei Medical Centre, Tainan City, Taiwan.
出版信息
Br J Ophthalmol. 2013 Sep;97(9):1192-6. doi: 10.1136/bjophthalmol-2013-303265. Epub 2013 Jul 5.
BACKGROUND/AIMS: To investigate the risk of developing retinal vein occlusion (RVO) in patients with systemic lupus erythematosus (SLE).
METHODS
In this retrospective population-based cohort study, 6756 patients with SLE and 40 536 controls without SLE (1:6) were selected from the Taiwan National Health Insurance Research Database claims from 2001 to 2006.
RESULTS
The incidence of RVO was 3.46-times higher in the SLE group than in controls (5.61 vs 1.62 per 10 000 person-years) (adjusted HR=3.883, 95% CI 2.299 to 6.558) calculated using Cox proportional hazard regression. Age was an independent risk factor for RVO, with adjusted HRs of 4.842 for individuals aged ≥50 years compared with those 0-49 years. For each age subgroup, the risk of RVO was significantly higher only in the 0-49-year-old SLE group than in controls. In the 0-49-year-old SLE group the incidence of developing RVO was 7.92 times higher (95% CI 3.60 to 17.45) in the SLE group than in the 0-49-year-old controls. In women with SLE, the incidence of developing RVO was 3.33-times higher (95% CI 1.88 to 5.90) than in female controls.
CONCLUSIONS
SLE was significantly associated with an increased risk of developing RVO.
背景/目的：调查系统性红斑狼疮（SLE）患者发生视网膜静脉阻塞（RVO）的风险。
方法
在这项回顾性基于人群的队列研究中，我们从 2001 年至 2006 年的台湾全民健康保险研究数据库理赔记录中选择了 6756 例 SLE 患者和 40536 例无 SLE 的对照者（1:6）。
结果
SLE 组的 RVO 发生率是对照组的 3.46 倍（5.61 比 1.62 每 10000 人年）（使用 Cox 比例风险回归计算，调整后的 HR=3.883，95%CI 2.299 至 6.558）。年龄是 RVO 的独立危险因素，与 0-49 岁相比，年龄≥50 岁者的调整 HR 为 4.842。对于每个年龄亚组，仅在 0-49 岁的 SLE 组中，RVO 的风险明显高于对照组。在 0-49 岁的 SLE 组中，SLE 组发生 RVO 的风险是 0-49 岁对照组的 7.92 倍（95%CI 3.60 至 17.45）。在 SLE 女性中，发生 RVO 的风险比女性对照组高 3.33 倍（95%CI 1.88 至 5.90）。
结论
SLE 与发生 RVO 的风险显著增加相关。
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