银屑病患者视网膜静脉阻塞的风险：一项基于人群的队列研究。

RISK OF RETINAL VEIN OCCLUSION IN PATIENTS WITH PSORIASIS: A Population-Based Cohort Study.

作者信息

Yen Yung-Chang, Weng Shih-Feng, Lai Feng-Jie, Lin Yung-Song

机构信息

*Department of Ophthalmology, Chi Mei Medical Center, Liou-Ying, Tainan City, Taiwan; †Department of Nursing, Min Hwei College of Health Care Management, Tainan City, Taiwan; ‡Department of Medical Research, Chi Mei Medical Center, Yung-Kang District, Tainan City, Taiwan; §Department of Hospital and Health Care Administration, Chia-Nan University of Pharmacy and Science, Ren De District, Tainan City, Taiwan; ¶Department of Dermatology, Chi Mei Medical Center, Yung-Kang District, Tainan City, Taiwan; **Center for General Education, Southern Taiwan University of Science and Technology, Tainan, Taiwan; ††Department of Otolaryngology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; and ‡‡Department of Otolaryngology, Chi Mei Medical Center, Yung-Kang District, Tainan City, Taiwan.

出版信息

Retina. 2015 Sep;35(9):1786-94. doi: 10.1097/IAE.0000000000000536.

DOI:10.1097/IAE.0000000000000536

PMID:25856017

Abstract

PURPOSE

To investigate the risk of developing retinal vein occlusion (RVO) in patients with psoriasis.

METHODS

In this retrospective population-based cohort study, 30,198 patients with psoriasis (Psoriasis((+)) group) and 30,198 controls without psoriasis (Psoriasis((−)) group) between 2001 and 2006 from the Taiwan National Health Insurance Research Database were selected.

RESULTS

The incidence of RVO was 1.46 times higher in the Psoriasis((+)) group than in the Psoriasis((−)) group (3.61 vs. 2.47/10,000 person-years) (adjusted hazard ratio = 1.50; 95% confidence interval = 1.07-2.10) calculated using Cox proportional hazard regression. Age was an independent risk factor for RVO (adjusted hazard ratio: 11.9 for patients 65 years or older vs. 1.00 for those 0-49 years old). In the 65 years or older Psoriasis((+)) group, the incidence of developing RVO was 1.97 times higher (95% confidence interval = 1.19-3.26) than in the 65 years or older Psoriasis((−)) group. In Psoriasis((+)) women, the incidence of developing RVO was 1.82 times higher (95% = 1.05-3.14) than in Psoriasis((−)) women. For the subgroup with comorbid hypertension, the incidence of developing RVO was 2.07 times higher (95% confidence interval = 1.22-3.50) in the Psoriasis((+)) group than in the Psoriasis((−)) group.

CONCLUSION

Psoriasis was significantly associated with a higher risk of developing RVO.

摘要

目的

探讨银屑病患者发生视网膜静脉阻塞（RVO）的风险。

方法

在这项基于人群的回顾性队列研究中，从台湾国民健康保险研究数据库选取了2001年至2006年间的30198例银屑病患者（银屑病（+）组）和30198例无银屑病的对照者（银屑病（-）组）。

结果

使用Cox比例风险回归计算得出，银屑病（+）组RVO的发病率比银屑病（-）组高1.46倍（3.61对2.47/10000人年）（调整后的风险比=1.50；95%置信区间=1.07-2.10）。年龄是RVO的独立危险因素（调整后的风险比：65岁及以上患者为11.9，0-49岁患者为1.00）。在65岁及以上的银屑病（+）组中，发生RVO的发病率比65岁及以上的银屑病（-）组高1.97倍（95%置信区间=1.19-3.26）。在银屑病（+）女性中，发生RVO的发病率比银屑病（-）女性高1.82倍（95%=1.05-3.14）。对于合并高血压的亚组，银屑病（+）组发生RVO的发病率比银屑病（-）组高2.07倍（95%置信区间=1.22-3.50）。