Department of Ophthalmology, Massachusetts Eye & Ear Infirmary, Harvard Medical School, Boston, USA.
Br J Ophthalmol. 2013 Sep;97(9):1197-201. doi: 10.1136/bjophthalmol-2013-303189. Epub 2013 Jul 5.
To compare functional and anatomical outcomes after idiopathic epiretinal membrane (ERM) peeling combined with phacoemulsification and intraocular lens implantation versus ERM peeling alone.
A retrospective, non-randomised comparative case series study was conducted of 81 eyes from 79 patients who underwent ERM peeling at the Beth Israel Deaconess Medical Center between 2001 and 2010. Eyes that underwent combined surgery for ERM and cataracts (group 1) were compared with those that had ERM peeling alone (group 2) with respect to best-corrected visual acuity at 6 months and 1 year after surgery, postoperative central macular thickness (CMT) as measured on optical coherence tomography, and rates of complications, including elevated intraocular pressure (IOP), ERM recurrence and need for reoperation.
Mean logMAR visual acuity improved significantly in both groups at 6 months (p<0.001) and 1 year (p<0.001) after surgery. There was no statistical difference between the two groups in visual acuity improvement at 6 months (p=0.108) or 1 year (p=0.094). Mean CMT of both groups also significantly decreased after surgery (p=0.002), with no statistical difference in CMT reduction between the two groups, but a trend toward less CMT reduction in group 1 (p=0.061). The rates of complications, including IOP elevation, ERM recurrence and frequency of reoperation, were similar in the two groups, with non-statistical trends toward greater ERM recurrence (p=0.084) and need for reoperation (p=0.096) in those that had combined surgery.
Combined surgery for ERMs and cataracts may potentially be as effective as membrane peeling alone with respect to visual and anatomical outcomes. Further studies are necessary to determine if there may be greater ERM recurrence or need for reoperation after combined surgery.
比较特发性视网膜内界膜(ERM)剥除联合白内障超声乳化吸除及人工晶状体植入与单纯 ERM 剥除后的功能和解剖结果。
对 2001 年至 2010 年间在 Beth Israel Deaconess Medical Center 接受 ERM 剥除术的 79 例 81 只眼进行回顾性、非随机对照病例系列研究。将接受 ERM 合并白内障手术的眼(第 1 组)与单纯行 ERM 剥除术的眼(第 2 组)进行比较,比较指标包括术后 6 个月和 1 年的最佳矫正视力、光学相干断层扫描(OCT)测量的术后中心黄斑厚度(CMT)以及包括眼压升高、ERM 复发和需要再次手术在内的并发症发生率。
两组患者术后 6 个月(p<0.001)和 1 年(p<0.001)的 logMAR 视力均显著提高,两组间 6 个月(p=0.108)和 1 年(p=0.094)的视力改善无统计学差异。两组术后 CMT 均显著降低(p=0.002),两组间 CMT 降低无统计学差异,但第 1 组 CMT 降低趋势较小(p=0.061)。两组的并发症发生率(包括眼压升高、ERM 复发和再次手术的频率)相似,第 1 组的 ERM 复发(p=0.084)和再次手术(p=0.096)有更高的趋势,但无统计学意义。
ERM 合并白内障手术在视力和解剖结果方面可能与单纯膜剥除术同样有效。需要进一步的研究来确定在联合手术后是否会有更高的 ERM 复发率或需要再次手术。