Banwari Girish H, Parmar Chirag D, Kandre Dhiraj D
Department of Psychiatry, Sheth V.S. General Hospital, Ahmedabad, Gujarat, India.
Indian J Psychol Med. 2013 Jan;35(1):84-6. doi: 10.4103/0253-7176.112213.
Following seizure control with antiepileptic drugs and normalization of electroencephalogram, behavioral problem may appear for the first time in an epileptic patient. This phenomenon has been termed 'alternative psychosis'. However, it remains poorly understood in absence of any definite diagnostic criteria, and there are no specific guidelines to treat the condition. Here we report a case of an untreated patient of epilepsy of 13 years duration, who had onset of first episode non-specific aggressive behavior within 1 week after starting treatment with sodium valproate, which responded adequately to a short course of low dose risperidone. We conclude that alternative psychosis may have a variable clinical presentation and may respond favorably to antipsychotic drugs.
在使用抗癫痫药物控制癫痫发作且脑电图恢复正常后，癫痫患者可能首次出现行为问题。这种现象被称为“交替性精神病”。然而，由于缺乏明确的诊断标准，对其仍知之甚少，并且没有治疗该病症的具体指南。在此，我们报告一例病程长达13年的未经治疗的癫痫患者，该患者在开始使用丙戊酸钠治疗后1周内首次出现非特异性攻击性行为发作，低剂量利培酮短疗程治疗对此反应良好。我们得出结论，交替性精神病可能有多种临床表现，对抗精神病药物可能反应良好。
