Department of Pharmacology, Malda Medical College, Malda, India.
Indian J Pharmacol. 2013 May-Jun;45(3):223-6. doi: 10.4103/0253-7613.111900.
To determine the aqueous and plasma concentrations of moxifloxacin administered topically alone and with flurbiprofen in patients undergoing cataract surgery.
A total of 50 subjects scheduled for routine cataract surgery were randomly allocated to two groups (n = 25 each). Group-1 patients were treated with topical moxifloxacin alone: One drop 6 times/day for 3 days before surgery and one drop 4 times on the day of surgery: Group-2 patients were treated with topical moxifloxacin as in Group-1 and with topical flurbiprofen: One drop 4 times/day for 3 days before and on the day of surgery. The interval between two drugs was 30 min for last 3 days and 15 min on the day of surgery. Last dose was administered 1 h before aqueous humor and blood sampling for both the groups. The antibiotic concentration in aqueous humor and plasma were determined by using high performance liquid chromatography.
The mean concentration of moxifloxacin in aqueous humor was 1.71 ± 0.82 mg/ml in Group-1 and 2.39 ± 1.34 mg/ml in Group-2. Concentrations of moxifloxacin in aqueous humor were significantly higher in Group-2 than that of Group-1.
Flurbiprofen may increase the concentration of moxifloxacin in aqueous humor.
确定单独局部使用莫西沙星和联合氟比洛芬治疗白内障手术患者的房水和血浆浓度。
共 50 例拟行常规白内障手术的患者被随机分为两组（每组 n = 25）。组 1 患者单独局部使用莫西沙星：术前 3 天每天滴 6 次，手术当天滴 4 次；组 2 患者以组 1 的方式局部使用莫西沙星，并联合局部使用氟比洛芬：术前 3 天和手术当天每天滴 4 次。两种药物之间的间隔为最后 3 天 30 分钟，手术当天 15 分钟。两组最后一次给药均在房水和血液取样前 1 小时进行。通过高效液相色谱法测定房水中的抗生素浓度。
组 1 房水中莫西沙星的平均浓度为 1.71 ± 0.82mg/ml，组 2 为 2.39 ± 1.34mg/ml。组 2 房水中莫西沙星的浓度明显高于组 1。
氟比洛芬可能会增加房水中莫西沙星的浓度。
