评价别嘌醇和非布司他在小鼠抑郁行为模型中的作用。
Evaluation of effect of allopurinol and febuxostat in behavioral model of depression in mice.
机构信息
Department of Pharmacology, T.N. Medical College and B.Y.L. Nair Ch. Hospital, Mumbai, Maharashtra, India.
出版信息
Indian J Pharmacol. 2013 May-Jun;45(3):244-7. doi: 10.4103/0253-7613.111922.
Abstract
OBJECTIVE
To evaluate the effects of allopurinol and febuxostat on depression using Forced Swim Test (FST) in mice.
MATERIALS AND METHODS
Allopurinol (39 mg/kg p. o) and febuxostat (15.6 mg/kg p. o) were administered once daily for 21 successive days to Swiss Albino mice. On the 21(st) day, the effect of the drug on locomotion was tested using photo-actometer followed by the recording of immobility period in the FST and the results were compared with the standard drug fluoxetine (10 mg/kg p. o).
RESULTS
Allopurinol and febuxostat expressed significant antidepressant like effect as indicated by reduction in the immobility period of mice in the FST as compared to control group. The effects of allopurinol and febuxostat were found to be comparable to that of fluoxetine.
CONCLUSION
The results of the present study indicate that allopurinol and febuxostat possess significant antidepressant like activity.
摘要
目的
通过强迫游泳试验（FST）评估别嘌醇和非布司他对小鼠抑郁的影响。
材料和方法
别嘌醇（39mg/kg，po）和非布司他（15.6mg/kg，po）每天给药 1 次，连续 21 天。在第 21 天，使用光测计测试药物对运动的影响，随后记录 FST 中的不动期，将结果与标准药物氟西汀（10mg/kg，po）进行比较。
结果
别嘌醇和非布司他均表现出明显的抗抑郁样作用，表现为与对照组相比，小鼠在 FST 中的不动期减少。别嘌醇和非布司他的作用与氟西汀相当。
结论
本研究结果表明，别嘌醇和非布司他具有显著的抗抑郁样活性。
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