Toker Lilach, Amar Shirly, Bersudsky Yuly, Benjamin Jonathan, Klein Ehud
Psychiatry Research Unit, Faculty of Health Sciences, Ben-Gurion University of the Negev, and Mental Health Center, Beersheva, Israel.
Isr J Psychiatry Relat Sci. 2010;47(1):46-55.
The involvement of the serotonergic system in the pathophysiology and treatment of affective disorders has been strongly implicated. The tryptophan depletion paradigm is widely used to study the effect of lowering serotonin levels. However, the effects observed in such studies are inconsistent and sometimes contradictory. The present review summarizes and discusses these discrepancies, emphasizing the importance of methodological details such as acute versus chronic tryptophan depletion, patients diagnosis and disease state: euthymic versus acute phase and previous drug treatment. Acute tryptophan depletion as a predictive test for personalized antidepressant treatment is suggested.
血清素能系统参与情感障碍的病理生理学过程及治疗已得到有力证实。色氨酸耗竭范式被广泛用于研究降低血清素水平的效果。然而，此类研究中观察到的效果并不一致，有时甚至相互矛盾。本综述总结并讨论了这些差异，强调了方法学细节的重要性，如急性与慢性色氨酸耗竭、患者诊断及疾病状态：心境正常期与急性期以及既往药物治疗情况。有人提出将急性色氨酸耗竭作为个性化抗抑郁治疗的预测性测试。
