Leach Ben I, Sun Bonnie, Petrovic Lydia, Liu Stephen V
Departments of Medicine, Los Angeles, CA 90033, USA.
Oncol Lett. 2013 Jun;5(6):1859-1861. doi: 10.3892/ol.2013.1303. Epub 2013 Apr 12.
Although often localized at diagnosis, nasopharyngeal carcinoma (NPC) has an established potential for distant metastasis. Breast metastasis from NPC is an uncommon presentation. In the present case study, the fifth reported case of breast metastasis from NPC is presented and the use of Epstein-Barr virus testing is demonstrated for the confirmation of this diagnosis. A 49-year-old female was diagnosed with advanced NPC and developed a unilateral breast mass. The biopsy was indicative of a primary breast carcinoma. Subsequent Epstein-Barr virus testing was positive in the primary tumor and the breast mass, establishing the true diagnosis of NPC metastasis to the breast. In summary, breast metastasis from NPC is an uncommon presentation and Epstein-Barr virus testing is suitable for confirmation of the diagnosis and exclusion of primary breast cancer.
尽管鼻咽癌（NPC）在诊断时通常局限于局部，但它具有远处转移的潜在可能。NPC转移至乳腺是一种不常见的表现。在本病例研究中，呈现了第五例报道的NPC转移至乳腺的病例，并展示了使用爱泼斯坦-巴尔病毒检测来确诊该病例。一名49岁女性被诊断为晚期NPC，并出现单侧乳腺肿块。活检提示原发性乳腺癌。随后，原发性肿瘤和乳腺肿块的爱泼斯坦-巴尔病毒检测均呈阳性，从而确诊为NPC转移至乳腺。总之，NPC转移至乳腺是一种不常见的表现，爱泼斯坦-巴尔病毒检测适用于确诊及排除原发性乳腺癌。
