Mao Xia, Liu Longlong, Zhang Bing, Zhang Donghua
Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China.
Oncol Lett. 2013 Jun;5(6):1867-1871. doi: 10.3892/ol.2013.1306. Epub 2013 Apr 16.
The reversion-inducing cysteine-rich protein with Kazal motifs () gene was originally identified as a transformation suppressor gene that is widely expressed in normal tissues. In tumor tissues, expression levels are significantly reduced, and the downregulation of has been implicated in tumors that are more aggressive with a poor prognosis. In the present study, expression in peripheral T-cell lymphoma (PTCL; n=82) was examined using immunohistochemistry, and its correlation with clinicopathological factors was analyzed. According to the proportion of positively-stained cells and the staining intensity (SI), the patients were categorized into -negative or -positive groups. expression was observed in 30 of the 82 patients (36.6%). The 3-year survival rate of the patients with -positive tumors (65.5%) was significantly high compared with that of the patients with -negative tumors (20.3%; P=0.046). Reduced expression was found to be significantly correlated with extranodal lymphomatous involvement (P=0.012). The survival analysis showed that -negative expression was an independent and significant factor for predicting a poor prognosis. status is a useful prognostic factor for assessing the biological behavior in PTCL.
含Kazal基序的逆转诱导富含半胱氨酸蛋白（）基因最初被鉴定为一种在正常组织中广泛表达的肿瘤抑制基因。在肿瘤组织中，其表达水平显著降低，且该基因的下调与侵袭性更强、预后较差的肿瘤有关。在本研究中，采用免疫组织化学方法检测了外周T细胞淋巴瘤（PTCL；n = 82）中的表达情况，并分析了其与临床病理因素的相关性。根据阳性染色细胞的比例和染色强度（SI），将患者分为阴性或阳性组。82例患者中有30例（36.6%）观察到表达。阳性肿瘤患者的3年生存率（65.5%）显著高于阴性肿瘤患者（20.3%；P = 0.046）。发现表达降低与结外淋巴瘤累及显著相关（P = 0.012）。生存分析表明，阴性表达是预测预后不良的一个独立且显著的因素。状态是评估PTCL生物学行为的一个有用的预后因素。
