Neurology Department.
Amyotroph Lateral Scler Frontotemporal Degener. 2013 Dec;14(7-8):598-603. doi: 10.3109/21678421.2013.808225. Epub 2013 Jul 8.
The incidence of amyotrophic lateral sclerosis (ALS) ranges from 1.7 to 2.3 per 100,000 persons worldwide. Few epidemiological studies have been published in Latin America. The aim of this study was to estimate the incidence and prevalence of ALS in an HMO (Health Maintenance Organization) of Buenos Aires, capital city of Argentina. The population studied was affiliates of the Italian Hospital Medical Care Program, whose distribution across age and gender strata is similar to the population of Buenos Aires. Cases were detected from 1 January 2003 to 31 December 2010. Incidence density (ID) and prevalence for ALS were estimated for the whole period and at 31 December 2010, respectively. During the seven-year study period, the crude ID estimated was 3.17 per 100,000 person-years (95% CI 2.24-4.48) and the age-adjusted ID for the Buenos Aires population was 2.23 per 100,000 person-years (95% CI 1.45-3.01). Point prevalence at 31 December 2010 was 8.86 per 100,000 persons (95% CI 4.05-13.68). Mean age at diagnosis was 72.29 years (SD 8.5). In conclusion, estimated age-adjusted ID and prevalence of ALS were similar to the incidence and prevalence rates found in other geographical areas.
全世界肌萎缩侧索硬化症（ALS）的发病率为每 10 万人中有 1.7 至 2.3 人。在拉丁美洲发表的此类流行病学研究较少。本研究旨在评估阿根廷首都布宜诺斯艾利斯一家健康维护组织（HMO）中 ALS 的发病率和患病率。研究人群为意大利医院医疗保健计划的成员，其年龄和性别分布与布宜诺斯艾利斯的人口相似。病例从 2003 年 1 月 1 日至 2010 年 12 月 31 日进行检测。分别对整个时期和 2010 年 12 月 31 日的 ALS 发病率密度（ID）和患病率进行了估计。在七年的研究期间，估计的粗发病率为每 100,000 人年 3.17 例（95%CI 2.24-4.48），调整布宜诺斯艾利斯人口年龄后的发病率为每 100,000 人年 2.23 例（95%CI 1.45-3.01）。2010 年 12 月 31 日的时点患病率为每 100,000 人 8.86 例（95%CI 4.05-13.68）。诊断时的平均年龄为 72.29 岁（SD 8.5）。总之，估计的年龄调整发病率和 ALS 患病率与其他地理区域的发病率和患病率相似。
