miR-34 家族在人类癌症中的功能作用。
Functional role of miR-34 family in human cancer.
机构信息
Department of Medical Oncology, First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, 233004, China.
出版信息
Curr Drug Targets. 2013 Sep;14(10):1185-91. doi: 10.2174/13894501113149990191.
Recently, microRNAs (miRNAs) including miR-34 family have been found to play a critical role in tumorigenesis through regulating the expression of its target genes, which are involved in many cellular processes such as cell proliferation, survival, apoptosis, migration, invasion and angiogenesis. Thus, this review described the role of miR-34 family and how its deregulation is involved in the development and progression of human malignances. Moreover, we described the potential role of miR-34 as a novel biomarker for tumor diagnosis. Furthermore, we summarized that miR-34 family could be up-regulated by natural compounds in human cancers. Therefore, targeting miR-34 family could be a novel strategy for achieving better treatment outcome of cancer patients in the future.
最近，miRNAs（miRNA）包括 miR-34 家族已被发现通过调节其靶基因的表达在肿瘤发生中发挥关键作用，这些靶基因参与许多细胞过程，如细胞增殖、存活、凋亡、迁移、侵袭和血管生成。因此，本综述描述了 miR-34 家族的作用及其失调如何参与人类恶性肿瘤的发展和进展。此外，我们描述了 miR-34 作为肿瘤诊断新型生物标志物的潜在作用。此外，我们总结到 miR-34 家族可在人类癌症中被天然化合物上调。因此，靶向 miR-34 家族可能是未来实现癌症患者更好治疗效果的新策略。
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