Orang Ayla Valinezhad, Safaralizadeh Reza, Hosseinpour Feizi Mohammad Ali
Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Islamic Republic of Iran E-mail :
Asian Pac J Cancer Prev. 2014;15(2):577-83. doi: 10.7314/apjcp.2014.15.2.577.
The recent discovery of tiny microRNAs (miRNAs) has brought about awareness of a new class of regulators of diverse pathways in many physiological and pathological processes, such as tumorigenesis. They modulate gene expression by targeting plethora of mRNAs, mostly reducing the protein yield of a targeted mRNA. With accumulation of information on characteristics of miR-205, complex and in some cases converse roles of miR-205 in tumor initiation, progression and metastasis are emerging. miR-205 acts either as an oncogene via facilitating tumor initiation and proliferation, or in some cases as a tumor suppressor through inhibiting proliferation and invasion. The aim of this review is to discuss miR-205 roles in different types of cancers. Given the critical effects of deregulated miR-205 on processes involved in tumorigenesis, they hold potential as novel therapeutic targets and biomarkers.
微小 microRNA（miRNA）的近期发现，使人们认识到一类新的调控因子，它们参与许多生理和病理过程（如肿瘤发生）的多种信号通路。它们通过靶向大量 mRNA 来调节基因表达，大多会降低靶向 mRNA 的蛋白质产量。随着关于 miR-205 特性的信息不断积累，miR-205 在肿瘤起始、进展和转移过程中复杂且在某些情况下相反的作用正在显现。miR-205 既可以通过促进肿瘤起始和增殖而充当癌基因，也在某些情况下通过抑制增殖和侵袭而作为肿瘤抑制因子。本综述的目的是讨论 miR-205 在不同类型癌症中的作用。鉴于 miR-205 失调对肿瘤发生相关过程的关键影响，它们有望成为新的治疗靶点和生物标志物。
