Matzku S, Moldenhauer G, Kalthoff H, Canevari S, Colnaghi M, Schuhmacher J, Bihl H
Institute of Radiology and Pathophysiology, German Cancer Research Center, Heidelberg.
Br J Cancer Suppl. 1990 Jul;10:1-5.
Internalization of monoclonal antibody (MAb) conjugates is an important feature of tumour targeting, both with respect to the therapeutic action of substances coupled to the antibody and to retention of radionuclides. Problems of analysing internalization in vitro and in vivo, of manipulating internalization, and of evaluating the involvement of normal tissues are illustrated by recent experimental data and are discussed in the light of published evidence.
单克隆抗体（MAb）偶联物的内化是肿瘤靶向的一个重要特征，这在与抗体偶联的物质的治疗作用以及放射性核素的保留方面均如此。近期的实验数据说明了在体外和体内分析内化、操纵内化以及评估正常组织参与情况的问题，并根据已发表的证据进行了讨论。
