Qorbani Mostafa, Bazrafshan Hamid Reza, Aghaei Mehrdad, Dashti Hossien Shadpour, Rezapour Aziz, Asayesh Hamid, Mohammadi Rasool, Mohammadi Younes, Ansari Hossein, Mansourian Morteza
Department of Health Education, Ilam University of Medical Sciences, Ilam, Iran.
J Diabetes Metab Disord. 2013 Jul 8;12(1):38. doi: 10.1186/2251-6581-12-38.
Osteoporosis is the most common metabolic bone disease with complicated, multifactorial and heterogenic nature that has no known pathological cause. As the role of Diabetes Mellitus (DM) and thyroid dysfunctions in the prevalence of osteoporosis is not exactly known, therefore this study was designed to evaluate the probable association between osteoporosis with DM and thyroid dysfunctions in Iranian patients.
In this cross-sectional study, 300 subjects out of the total number of patients referring to Gorgan bone densitometry centers (3000subjects) were selected via random sampling method in 2009. Individual characteristics, DM, thyroid dysfunctions and densitometry results were collected from densitometry records. Data analysis was carried out by SPSS version 16 software and by using Chi square and T-test. The level of significance in all tests was considered 0.05.
The mean of T-score in lumbar and femoral areas of diabetic patients were -0.87 ± 1.08 and -1.94 ± 1.33 and in patient with thyroid dysfunctions was -0.80 ± 1.09 and -1.64 ± 1.24 respectively. The mean of BMD in lumbar and femoral areas of diabetic patients were 0.96 ± 0.19 and 0.75 ± 0.19 and in patient with thyroid dysfunctions were 0.96 ± 0.17 and 0.76 ±0.19 respectively. The mean of BMI in osteoporotic subjects in the lumbar and femoral areas were 25.94 ± 5.62 and 26.95 ± 5.20 respectively. The association between BMI and BMD in the lumbar and femoral areas were statistically significant, but the association between DM and thyroid dysfunctions with BMD and T-score in the femoral and lumbar areas was not statistically significant (P-value > 0.05).
The results of current study show that there is no association between DM and thyroid dysfunctions with osteoporosis.
骨质疏松症是最常见的代谢性骨病，其性质复杂、多因素且具有异质性，目前尚无已知的病理原因。由于糖尿病（DM）和甲状腺功能障碍在骨质疏松症患病率中的作用尚不完全清楚，因此本研究旨在评估伊朗患者中骨质疏松症与DM和甲状腺功能障碍之间可能存在的关联。
在这项横断面研究中，2009年通过随机抽样方法从转诊至戈尔甘骨密度测量中心的患者总数（3000名患者）中选取了300名受试者。从骨密度测量记录中收集个体特征、DM、甲状腺功能障碍和骨密度测量结果。使用SPSS 16版软件并通过卡方检验和T检验进行数据分析。所有检验的显著性水平均设定为0.05。
糖尿病患者腰椎和股骨区域的T值均值分别为-0.87±1.08和-1.94±1.33，甲状腺功能障碍患者的T值均值分别为-0.80±1.09和-1.64±1.24。糖尿病患者腰椎和股骨区域的骨密度均值分别为0.96±0.19和0.75±0.19，甲状腺功能障碍患者的骨密度均值分别为0.96±0.17和0.76±0.19。骨质疏松症患者腰椎和股骨区域的体重指数（BMI）均值分别为25.94±5.62和26.95±5.20。BMI与腰椎和股骨区域骨密度之间的关联具有统计学意义，但DM和甲状腺功能障碍与股骨和腰椎区域骨密度及T值之间的关联无统计学意义（P值>0.05）。
本研究结果表明，DM和甲状腺功能障碍与骨质疏松症之间不存在关联。
