National Heart and Lung Institute, Imperial College London, Royal Brompton and Harefield NHS Foundation Trust, Sydney Street, London SW3 6NP, UK.
Maturitas. 2013 Sep;76(1):10-21. doi: 10.1016/j.maturitas.2013.05.018. Epub 2013 Jul 6.
HRT is known to be effective for the relief of menopausal symptoms and prevention of osteoporosis. HRT should be tailored to the woman, enhancing the beneficial effects of the treatment while minimizing the risks. It is difficult to evaluate data on particular preparations of HRT and the different dosages in isolation. The purpose of this review is to highlight the efficacy and safety specific to oral estradiol and dydrogesterone combinations of four different dose strengths. A systematic literature search using Medline was carried out to identify studies containing efficacy or safety data. The findings of the retrieved publications confirm that estradiol and dydrogesterone combinations give very effective menopausal symptom relief and prevention of osteoporosis whilst maintaining a good safety profile. Data also show that these combinations of HRT give additional benefit to certain metabolic parameters including lipids, insulin, glucose and body fat distribution. By selecting the treatment and dose most suitable for each individual woman at her particular stage of menopause, the benefits can be optimized whilst mitigating the risks. HRT plays an important role in improving and maintaining women's health when used appropriately.
HRT 已被证实可有效缓解更年期症状和预防骨质疏松症。HRT 应根据女性个体情况进行调整，在最大程度降低风险的同时增强治疗的有益效果。单独评估特定 HRT 制剂和不同剂量的数据存在一定难度。本综述旨在重点介绍四种不同剂量强度的口服雌二醇和地屈孕酮联合制剂的疗效和安全性。采用 Medline 进行系统文献检索，以确定包含疗效或安全性数据的研究。检索到的文献研究结果证实，雌二醇和地屈孕酮联合制剂能非常有效地缓解更年期症状和预防骨质疏松症，同时保持良好的安全性。数据还表明，这些 HRT 联合制剂对某些代谢参数（包括血脂、胰岛素、血糖和体脂分布）也有额外益处。通过为每位处于特定绝经期阶段的女性选择最适合其个体情况的治疗和剂量，可以在降低风险的同时使获益最大化。HRT 在适当应用时对改善和维持女性健康起着重要作用。
