Ţiţ Delia Mirela, Pallag Annamaria, Iovan Ciprian, Furău Gheorghe, Furău Cristian, Bungău Simona
Dept. of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania.
Dept. of Preclinical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania.
Iran J Public Health. 2017 Nov;46(11):1528-1534.
The purpose of this study was to compare the effects of the phytoestrogens in relieving and/or suppressing the specific somatic-vegetative symptoms of menopause with those of the hormone therapy, administered in small doses.
The study was conducted in the County Clinical Emergency Hospital Oradea - Obstetric-Gynecological Ambulatory, and in private obstetrics-gynecology cabinets from Bihor County (NW Romania), from November 2011 to January 2014. Overall, 325 patients clinically diagnosed with specific postmenopausal symptomatology and not previously treated with phytoestrogens or hormone replacement therapy (HRT), were divided into 3 groups. Symptom assessment was performed with a standardized questionnaire named Menopause Rating Scale (MRS) in three phases: beginning of the treatment, after six months, and after one year. The administered doses for three different groups were as follows: 1 mg estradiol and 0.5 mg norethisterone acetate (NETA) p.o. daily (i.e. for the HRT group); 40 mg of isoflavones p.o. daily - i.e. 2 capsules of 40% standardized extract containing 20 mg of pure isoflavones: Genistein, Daidzein, and Glycitein (i.e. for the group with phytoestrogens); and no trreatment for the control group.
The evolution of the somatic-vegetative symptoms was better in both groups treated either with phytoestrogens or HRT (<0.001) as opposed to the higher percentage of patients with stationary symptoms in the control group (i.e. 37.74% for control group, 16.13% for the group treated with phytoestrogens, respectively 18.95% for the group treated with HRT).
Twelve months treatment study is a favorable evidence for the use of soy derived phytoestrogens in the treatment of somatic-vegetative symptoms at postmenopausal women.
本研究的目的是比较植物雌激素与小剂量激素疗法在缓解和/或抑制更年期特定躯体-植物神经症状方面的效果。
该研究于2011年11月至2014年1月在奥拉迪亚县临床急救医院 - 妇产科门诊以及比霍尔县（罗马尼亚西北部）的私立妇产科诊所进行。总体而言，325例临床诊断为绝经后特定症状且此前未接受过植物雌激素或激素替代疗法（HRT）治疗的患者被分为3组。使用名为更年期评定量表（MRS）的标准化问卷在三个阶段进行症状评估：治疗开始时、六个月后和一年后。三个不同组的给药剂量如下：每天口服1毫克雌二醇和0.5毫克醋酸炔诺酮（即HRT组）；每天口服40毫克异黄酮 - 即2粒含20毫克纯异黄酮（染料木黄酮、大豆苷元、黄豆黄素）的40%标准化提取物胶囊（即植物雌激素组）；对照组不进行治疗。
与对照组中症状无变化的患者比例较高（即对照组为37.74%，植物雌激素治疗组为16.13%，HRT治疗组为18.95%）相反，植物雌激素组和HRT组的躯体-植物神经症状改善情况更好（<0.001）。
为期十二个月的治疗研究为使用大豆衍生的植物雌激素治疗绝经后女性的躯体-植物神经症状提供了有力证据。
