EGFR 阻碍了 microRNA 的生物发生。
EGFR gets in the way of microRNA biogenesis.
机构信息
1] Department of Experimental Therapeutics and The Center for RNA Interference and Non-Coding RNAs, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA [2] Department of Gastroenterological Surgery, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita City, Osaka, Japan.
出版信息
Cell Res. 2013 Oct;23(10):1157-8. doi: 10.1038/cr.2013.87. Epub 2013 Jul 9.
Abstract
Recent studies suggest that microRNA (miRNA) processing is a key regulatory step in the miRNA biogenesis as well as its transcriptional control. In a paper recently published in Nature, Shen et al. revealed that epidermal growth factor receptor (EGFR) directly interacts with argonaute 2 (AGO2), a critical component of RNA-induced silencing complex (RISC), and inhibits the maturation of specific tumor suppressive miRNAs under hypoxic condition.
摘要
最近的研究表明，microRNA (miRNA) 加工是 miRNA 生物发生及其转录控制的关键调节步骤。在最近发表在《自然》杂志上的一篇论文中，Shen 等人揭示了表皮生长因子受体 (EGFR) 直接与 argonaute 2 (AGO2) 相互作用，AGO2 是 RNA 诱导沉默复合物 (RISC) 的关键组成部分，并且在缺氧条件下抑制特定肿瘤抑制 miRNA 的成熟。
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本文引用的文献
1
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Nature. 2013 May 16;497(7449):383-7. doi: 10.1038/nature12080. Epub 2013 May 1.
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Hypoxia potentiates microRNA-mediated gene silencing through posttranslational modification of Argonaute2.缺氧通过 Argonaute2 的翻译后修饰增强 microRNA 介导的基因沉默。
Mol Cell Biol. 2011 Dec;31(23):4760-74. doi: 10.1128/MCB.05776-11. Epub 2011 Oct 3.
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