Argonaute 调控：殊途同归

Argonaute regulation: two roads to the same destination.

机构信息

Biochemistry Center Regensburg (BZR), Laboratory for RNA Biology, University of Regensburg, Universitätsstrasse 31, 93053 Regensburg, Germany.

出版信息

Dev Cell. 2013 Jun 24;25(6):553-4. doi: 10.1016/j.devcel.2013.06.009.

DOI:10.1016/j.devcel.2013.06.009

PMID:23806615

Abstract

Reporting recently in Nature and Nature Structural and Molecular Biology, Shen et al. (2013) and Smibert et al. (2013) uncover mechanisms for Argonaute (Ago) protein regulation. Smibert et al. find that microRNA availability controls Ago levels, and Shen et al. show that epidermal growth factor receptor-mediated Ago2 phosphorylation affects Ago loading.

摘要

沈等（2013）和斯米伯特等（2013）在《自然》和《自然结构与分子生物学》杂志上发表的报告揭示了 Argonaute（AGO）蛋白调控的机制。斯米伯特等发现 microRNA 的可用性控制 Ago 的水平，沈等则表明表皮生长因子受体介导的 Ago2 磷酸化影响 Ago 的加载。