Department of Mathematics, Institute for Computational and Mathematical Engineering, Stanford University, Stanford, CA 94305, USA.
Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):E2752-61. doi: 10.1073/pnas.1216318110. Epub 2013 Jul 8.
Advances in solid-state technology have enabled the development of silicon photomultiplier sensor arrays capable of sensing individual photons. Combined with high-frequency time-to-digital converters (TDCs), this technology opens up the prospect of sensors capable of recording with high accuracy both the time and location of each detected photon. Such a capability could lead to significant improvements in imaging accuracy, especially for applications operating with low photon fluxes such as light detection and ranging and positron-emission tomography. The demands placed on on-chip readout circuitry impose stringent trade-offs between fill factor and spatiotemporal resolution, causing many contemporary designs to severely underuse the technology's full potential. Concentrating on the low photon flux setting, this paper leverages results from group testing and proposes an architecture for a highly efficient readout of pixels using only a small number of TDCs. We provide optimized design instances for various sensor parameters and compute explicit upper and lower bounds on the number of TDCs required to uniquely decode a given maximum number of simultaneous photon arrivals. To illustrate the strength of the proposed architecture, we note a typical digitization of a 60 × 60 photodiode sensor using only 142 TDCs. The design guarantees registration and unique recovery of up to four simultaneous photon arrivals using a fast decoding algorithm. By contrast, a cross-strip design requires 120 TDCs and cannot uniquely decode any simultaneous photon arrivals. Among other realistic simulations of scintillation events in clinical positron-emission tomography, the above design is shown to recover the spatiotemporal location of 99.98% of all detected photons.
固态技术的进步使得能够开发出能够感应单个光子的硅光电倍增器传感器阵列。与高频时间数字转换器 (TDC) 相结合,这项技术为能够高精度记录每个检测到的光子的时间和位置的传感器开辟了前景。这种能力可以显著提高成像精度,特别是对于低光子通量应用,如光探测和测距以及正电子发射断层扫描。对片上读出电路的需求在填充因子和时空分辨率之间施加了严格的权衡,导致许多当代设计严重低估了该技术的全部潜力。本文专注于低光子通量设置,利用群体测试的结果,提出了一种使用少量 TDC 对像素进行高效读出的架构。我们为各种传感器参数提供了优化的设计实例,并计算了唯一解码给定最大同时光子到达数所需的 TDC 数的明确上限和下限。为了说明所提出架构的优势,我们注意到仅使用 142 个 TDC 对典型的 60×60 光电二极管传感器进行数字化。该设计使用快速解码算法保证了多达四个同时光子到达的注册和唯一恢复。相比之下,交叉条设计需要 120 个 TDC,并且不能唯一解码任何同时的光子到达。在临床正电子发射断层扫描中闪烁事件的其他实际模拟中,上述设计被证明可以恢复所有检测到的光子的 99.98%的时空位置。