• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

数字硅光电倍增管在医学成像中的架构级优化

Architecture-Level Optimization on Digital Silicon Photomultipliers for Medical Imaging.

机构信息

Organisation Européenne Pour la Recherche Nucléaire, Experimental Physics Department, Esplanade des Particules 1, 1211 Meyrin, Switzerland.

Escuela de Ciencias, Ingeniería y Diseño, Universidad Europea de Valencia, Passeig de l'Albereda, 7, 46010 Valencia, Spain.

出版信息

Sensors (Basel). 2021 Dec 24;22(1):122. doi: 10.3390/s22010122.

DOI:10.3390/s22010122
PMID:35009665
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8749722/
Abstract

Silicon photomultipliers (SiPMs) are arrays of single-photon avalanche diodes (SPADs) connected in parallel. Analog silicon photomultipliers are built in custom technologies optimized for detection efficiency. Digital silicon photomultipliers are built in CMOS technology. Although CMOS SPADs are less sensitive, they can incorporate additional functionality at the sensor plane, which is required in some applications for an accurate detection in terms of energy, timestamp, and spatial location. This additional circuitry comprises active quenching and recharge circuits, pulse combining and counting logic, and a time-to-digital converter. This, together with the disconnection of defective SPADs, results in a reduction of the light-sensitive area. In addition, the pile-up of pulses, in space and in time, translates into additional efficiency losses that are inherent to digital SiPMs. The design of digital SiPMs must include some sort of optimization of the pixel architecture in order to maximize sensitivity. In this paper, we identify the most relevant variables that determine the influence of SPAD yield, fill factor loss, and spatial and temporal pile-up in the photon detection efficiency. An optimum of 8% is found for different pixel sizes. The potential benefits of molecular imaging of these optimized and small-sized pixels with independent timestamping capabilities are also analyzed.

摘要

硅光电倍增管 (SiPM) 是由多个单光子雪崩二极管 (SPAD) 并联组成的阵列。模拟硅光电倍增管是基于优化探测效率的定制技术构建的。数字硅光电倍增管则是基于 CMOS 技术构建的。尽管 CMOS SPAD 的灵敏度较低,但它们可以在传感器平面上集成额外的功能,这在某些应用中对于能量、时间戳和空间位置的精确检测是必需的。这些额外的电路包括有源猝灭和充电电路、脉冲组合和计数逻辑以及时间数字转换器。这与有缺陷的 SPAD 的断开一起导致光敏感区域的减少。此外,脉冲在空间和时间上的堆积会导致数字 SiPM 固有的额外效率损失。数字 SiPM 的设计必须包括某种像素架构的优化,以最大程度地提高灵敏度。在本文中,我们确定了决定 SPAD 产量、填充因子损失以及光子探测效率的空间和时间堆积影响的最相关变量。针对不同的像素尺寸,我们找到了 8%的最佳值。我们还分析了这些优化后的小型像素具有独立时间戳功能的分子成像的潜在优势。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a186/8749722/b765dc9828fc/sensors-22-00122-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a186/8749722/f16ed4075e7b/sensors-22-00122-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a186/8749722/a6c5d692f373/sensors-22-00122-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a186/8749722/83ada239df3a/sensors-22-00122-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a186/8749722/f0f2b603f876/sensors-22-00122-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a186/8749722/e73416e42e8c/sensors-22-00122-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a186/8749722/afb0d515581d/sensors-22-00122-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a186/8749722/7d7449c476d0/sensors-22-00122-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a186/8749722/917fa632e7b6/sensors-22-00122-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a186/8749722/54c69ce50a66/sensors-22-00122-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a186/8749722/b765dc9828fc/sensors-22-00122-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a186/8749722/f16ed4075e7b/sensors-22-00122-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a186/8749722/a6c5d692f373/sensors-22-00122-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a186/8749722/83ada239df3a/sensors-22-00122-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a186/8749722/f0f2b603f876/sensors-22-00122-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a186/8749722/e73416e42e8c/sensors-22-00122-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a186/8749722/afb0d515581d/sensors-22-00122-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a186/8749722/7d7449c476d0/sensors-22-00122-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a186/8749722/917fa632e7b6/sensors-22-00122-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a186/8749722/54c69ce50a66/sensors-22-00122-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a186/8749722/b765dc9828fc/sensors-22-00122-g010.jpg

相似文献

1
Architecture-Level Optimization on Digital Silicon Photomultipliers for Medical Imaging.数字硅光电倍增管在医学成像中的架构级优化
Sensors (Basel). 2021 Dec 24;22(1):122. doi: 10.3390/s22010122.
2
CMOS Time-to-Digital Converters for Biomedical Imaging Applications.用于生物医学成像应用的CMOS时间数字转换器
IEEE Rev Biomed Eng. 2023;16:627-652. doi: 10.1109/RBME.2021.3092197. Epub 2023 Jan 5.
3
0.16 µm⁻BCD Silicon Photomultipliers with Sharp Timing Response and Reduced Correlated Noise.0.16 µm⁻BCD 硅光电倍增管,具有快速定时响应和降低的相关噪声。
Sensors (Basel). 2018 Nov 3;18(11):3763. doi: 10.3390/s18113763.
4
Custom single-photon avalanche diode with integrated front-end for parallel photon timing applications.用于并行光子计时应用的集成前端定制单光子雪崩二极管。
Rev Sci Instrum. 2012 Mar;83(3):033104. doi: 10.1063/1.3692737.
5
The statistical distribution of the number of counted scintillation photons in digital silicon photomultipliers: model and validation.数字硅光电倍增管中闪烁光子计数的统计分布:模型与验证。
Phys Med Biol. 2012 Aug 7;57(15):4885-903. doi: 10.1088/0031-9155/57/15/4885. Epub 2012 Jul 13.
6
Towards a Multi-Pixel Photon-to-Digital Converter for Time-Bin Quantum Key Distribution.面向时分量子密钥分发的多像素光子到数字转换器。
Sensors (Basel). 2023 Mar 23;23(7):3376. doi: 10.3390/s23073376.
7
3D Photon-to-Digital Converter for Radiation Instrumentation: Motivation and Future Works.用于辐射仪器的3D光子到数字转换器:动机与未来工作
Sensors (Basel). 2021 Jan 16;21(2):598. doi: 10.3390/s21020598.
8
New silicon technologies enable high-performance arrays of Single Photon Avalanche Diodes.新型硅技术使单光子雪崩二极管的高性能阵列成为可能。
Proc SPIE Int Soc Opt Eng. 2013 May 29;8727:87270M-. doi: 10.1117/12.2016384.
9
The silicon photomultiplier: fundamentals and applications of a modern solid-state photon detector.硅光电倍增管:一种现代固态光子探测器的原理及应用。
Phys Med Biol. 2020 Aug 21;65(17):17TR01. doi: 10.1088/1361-6560/ab7b2d.
10
Experimental time resolution limits of modern SiPMs and TOF-PET detectors exploring different scintillators and Cherenkov emission.现代硅光电倍增管和飞行时间正电子发射断层扫描探测器探索不同闪烁体和切伦科夫发射的实验时间分辨率限制。
Phys Med Biol. 2020 Jan 17;65(2):025001. doi: 10.1088/1361-6560/ab63b4.

本文引用的文献

1
PennPET Explorer: Human Imaging on a Whole-Body Imager.PennPET Explorer:全身成像仪上的人体成像。
J Nucl Med. 2020 Jan;61(1):144-151. doi: 10.2967/jnumed.119.231845. Epub 2019 Sep 27.
2
A 250 m Direct Time-of-Flight Ranging System Based on a Synthesis of Sub-Ranging Images and a Vertical Avalanche Photo-Diodes (VAPD) CMOS Image Sensor.基于子距离图像合成和垂直雪崩光电二极管 (VAPD) CMOS 图像传感器的 250m 直接飞行时间测距系统。
Sensors (Basel). 2018 Oct 27;18(11):3642. doi: 10.3390/s18113642.
3
Performance Evaluation of the Vereos PET/CT System According to the NEMA NU2-2012 Standard.
根据 NEMA NU2-2012 标准对 Vereos PET/CT 系统进行性能评估。
J Nucl Med. 2019 Apr;60(4):561-567. doi: 10.2967/jnumed.118.215541. Epub 2018 Oct 25.
4
A Prototype High-Resolution Small-Animal PET Scanner Dedicated to Mouse Brain Imaging.一款专门用于小鼠脑成像的高分辨率小动物正电子发射断层扫描仪原型。
J Nucl Med. 2016 Jul;57(7):1130-5. doi: 10.2967/jnumed.115.165886. Epub 2016 Mar 24.
5
A high-throughput time-resolved mini-silicon photomultiplier with embedded fluorescence lifetime estimation in 0.13 μm CMOS.一种在0.13μm互补金属氧化物半导体中嵌入荧光寿命估计功能的高通量时间分辨微型硅光电倍增管。
IEEE Trans Biomed Circuits Syst. 2012 Dec;6(6):562-70. doi: 10.1109/TBCAS.2012.2222639.
6
ALBIRA: a small animal PET∕SPECT∕CT imaging system.ALBIRA:小动物 PET/SPECT/CT 成像系统。
Med Phys. 2013 May;40(5):051906. doi: 10.1118/1.4800798.
7
The lower bound on the timing resolution of scintillation detectors.闪烁探测器时间分辨率的下限。
Phys Med Biol. 2012 Apr 7;57(7):1797-814. doi: 10.1088/0031-9155/57/7/1797. Epub 2012 Mar 13.
8
Physical and clinical performance of the mCT time-of-flight PET/CT scanner.mCT 飞行时间 PET/CT 扫描仪的物理和临床性能。
Phys Med Biol. 2011 Apr 21;56(8):2375-89. doi: 10.1088/0031-9155/56/8/004. Epub 2011 Mar 22.
9
Benefit of time-of-flight in PET: experimental and clinical results.正电子发射断层扫描中飞行时间的优势:实验与临床结果
J Nucl Med. 2008 Mar;49(3):462-70. doi: 10.2967/jnumed.107.044834. Epub 2008 Feb 20.
10
GATE: a simulation toolkit for PET and SPECT.GATE:正电子发射断层扫描(PET)和单光子发射计算机断层扫描(SPECT)的模拟工具包。
Phys Med Biol. 2004 Oct 7;49(19):4543-61. doi: 10.1088/0031-9155/49/19/007.